Protein landscape of the brush border membrane of first instar larvae of Frankliniella occidentalis, the western flower thrips

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Pubblicato in:PLoS One vol. 20, no. 6 (Jun 2025), p. e0326260
Autore principale: Maurastoni, Marlonni
Altri autori: Rotenberg, Dorith, Mishra, Ruchir, Bonning, Bryony C, Whitfield, Anna E
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Public Library of Science
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024 7 |a 10.1371/journal.pone.0326260  |2 doi 
035 |a 3223867772 
045 2 |b d20250601  |b d20250630 
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100 1 |a Maurastoni, Marlonni 
245 1 |a Protein landscape of the brush border membrane of first instar larvae of <i>Frankliniella occidentalis</i>, the western flower thrips 
260 |b Public Library of Science  |c Jun 2025 
513 |a Journal Article 
520 3 |a We investigated the protein composition of the brush border membrane of larval Frankliniella occidentalis (western flower thrips), an agriculturally significant crop pest and vector of plant pathogens. We developed a protocol for purifying brush border membrane vesicles (BBMVs) from first-instar larvae (L1) bodies and identified their protein composition by LC-MS/MS. From 2544 proteins identified, 469 were predicted to be secreted and part of the inner and outer plasma membrane leaflet using cell-localization prediction tools and homology with reviewed proteins in the UniProt database. Comparison to thrips tissue-specific proteomes revealed that 371 and 263 of the identified BBMV plasma membrane and secreted proteins matched the larval gut and adult salivary glands, respectively. Annotations of most of the proteins inferred ‘catalytic activity’ (56.3%) and ‘binding’ (49.6%), with an overrepresentation of proteins involved in protein digestion, specifically serine proteases, lipid transport, and ATPase activity. Bioinformatic-enabled comparisons to thrips tissue-specific proteomes and transcriptomes enabled us to predict the secretome and the plasma membrane proteins of larval thrips’ gut epithelial cells, providing new targets for thrips control. 
653 |a Transcriptomes 
653 |a Agricultural production 
653 |a Membranes 
653 |a Larvae 
653 |a Protein composition 
653 |a Insecticides 
653 |a Gastrointestinal tract 
653 |a Annotations 
653 |a Localization 
653 |a Brushes 
653 |a Secretome 
653 |a Proteins 
653 |a Flowers 
653 |a Catalytic activity 
653 |a Salivary gland 
653 |a Homology 
653 |a Epithelium 
653 |a Serine proteinase 
653 |a Insects 
653 |a Membrane proteins 
653 |a Proteomes 
653 |a Lipids 
653 |a Digestive system 
653 |a Epithelial cells 
653 |a Enzymes 
653 |a Composition 
653 |a Exocrine glands 
653 |a Salivary glands 
653 |a Frankliniella occidentalis 
653 |a Environmental 
700 1 |a Rotenberg, Dorith 
700 1 |a Mishra, Ruchir 
700 1 |a Bonning, Bryony C 
700 1 |a Whitfield, Anna E 
773 0 |t PLoS One  |g vol. 20, no. 6 (Jun 2025), p. e0326260 
786 0 |d ProQuest  |t Health & Medical Collection 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3223867772/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text  |u https://www.proquest.com/docview/3223867772/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text - PDF  |u https://www.proquest.com/docview/3223867772/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch