Exploring the Potential Association Between Inhaled Corticosteroid and Face Aging Risk: A Mendelian Randomization Study
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| Vydáno v: | Pharmaceuticals vol. 18, no. 6 (2025), p. 846-862 |
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| Další autoři: | , , , , |
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MDPI AG
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| On-line přístup: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 022 | |a 1424-8247 | ||
| 024 | 7 | |a 10.3390/ph18060846 |2 doi | |
| 035 | |a 3223930204 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 231548 |2 nlm | ||
| 100 | 1 | |a Li, Junpeng |u Department of Surgery Tohoku, University Graduate School of Medicine, Sendai 980-8575, Japan; li.junpeng.t1@dc.tohoku.ac.jp | |
| 245 | 1 | |a Exploring the Potential Association Between Inhaled Corticosteroid and Face Aging Risk: A Mendelian Randomization Study | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Background: Asthma is one of the most prevalent chronic diseases, affecting more than 300 million individuals globally. Inhaled corticosteroids (ICSs) are recommended as the primary therapy for managing and preventing asthma symptoms in current treatment guidelines. However, long-term use of ICSs could lead to multiple side effects, including skin changes. Methods: We identified ICS target genes using DrugBank and DGIdb databases and derived genetic instruments from cis-eQTL data in whole-blood samples (n = 31,684). GWAS data for facial aging traits (n = 423,999) and plasma metabolites (1400 metabolites, n = 8000) were analyzed. DNA methylation QTL (mQTL) data were used to explore epigenetic regulation. Mendelian randomization (MR) and colocalization analyses were performed to assess causality and shared genetic loci. Results: MR analysis suggested a significant link between genetically proxied ICSs (ORMDL3) and face aging in the European population. Further mediation analysis indicated that 5-Hydroxylysine partially mediates the relationship between ICSs and face aging. In addition, our analysis revealed the pleiotropic association of some novel DNA methylation sites of ORMDL3 with face aging, suggesting the possible regulatory mechanism that are involved in face aging. Conclusions: These findings, while exploratory, raise the hypothesis that ICSs may impact face aging through upregulation of ORMDL3 expression and 5-hydroxylysine metabolism and highlight the need for further pharmacological and clinical research to validate these potential effects. | |
| 653 | |a DNA methylation | ||
| 653 | |a Plasma | ||
| 653 | |a Gene expression | ||
| 653 | |a Asthma | ||
| 653 | |a Metabolism | ||
| 653 | |a Fibroblasts | ||
| 653 | |a Aging | ||
| 653 | |a Metabolites | ||
| 653 | |a Steroids | ||
| 700 | 1 | |a Liu Yaqiong |u Regenerative Medicine Institute (REMEDI), University of Galway, H91 TK33 Galway, Ireland; y.liu14@universityofgalway.ie (Y.L.); gujiewu08@gmail.com (G.W.) | |
| 700 | 1 | |a Wu Gujie |u Regenerative Medicine Institute (REMEDI), University of Galway, H91 TK33 Galway, Ireland; y.liu14@universityofgalway.ie (Y.L.); gujiewu08@gmail.com (G.W.) | |
| 700 | 1 | |a Yin Shanye |u Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; shanye.yin@einsteinmed.edu | |
| 700 | 1 | |a Cheng, Lin |u Regenerative Medicine Institute (REMEDI), University of Galway, H91 TK33 Galway, Ireland; y.liu14@universityofgalway.ie (Y.L.); gujiewu08@gmail.com (G.W.) | |
| 700 | 1 | |a Deng Wenjun |u Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA | |
| 773 | 0 | |t Pharmaceuticals |g vol. 18, no. 6 (2025), p. 846-862 | |
| 786 | 0 | |d ProQuest |t Research Library | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3223930204/abstract/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3223930204/fulltextwithgraphics/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3223930204/fulltextPDF/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |