Microbiota-Accessible Borates as Novel and Emerging Prebiotics for Healthy Longevity: Current Research Trends and Perspectives
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| Publicat a: | Pharmaceuticals vol. 18, no. 6 (2025), p. 766-794 |
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| Autor principal: | |
| Altres autors: | , , , , , , , , , , , , , , |
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MDPI AG
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| Accés en línia: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 022 | |a 1424-8247 | ||
| 024 | 7 | |a 10.3390/ph18060766 |2 doi | |
| 035 | |a 3223931358 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 231548 |2 nlm | ||
| 100 | 1 | |a Biţă Andrei |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 245 | 1 | |a Microbiota-Accessible Borates as Novel and Emerging Prebiotics for Healthy Longevity: Current Research Trends and Perspectives | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Review | ||
| 520 | 3 | |a Precision nutrition-targeted gut microbiota (GM) may have therapeutic potential not only for age-related diseases but also for slowing the aging process and promoting longer healthspan. Recent studies have shown that restoring a healthy symbiosis of GM by counteracting dysbiosis (DYS) through precise nutritional intervention is becoming a major target for extending healthspan. Microbiota-accessible borate (MAB) complexes, such as boron (B)–pectins (rhamnogalacturonan–borate) and borate–phenolic esters (diester chlorogenoborate), have a significant impact on healthy host–microbiota symbiosis (HMS). The mechanism of action of MABs involves the biosynthesis of the autoinducer-2–borate (AI-2B) signaling molecule, B fortification of the mucus gel layer by the MABs diet, inhibition of pathogenic microbes, and reversal of GM DYS, strengthening the gut barrier structure, enhancing immunity, and promoting overall host health. In fact, the lack of MAB complexes in the human diet causes reduced levels of AI-2B in GM, inhibiting the Firmicutes phylum (the main butyrate-producing bacteria), with important effects on healthy HMS. It can now be argued that there is a relationship between MAB-rich intake, healthy HMS, host metabolic health, and longevity. This could influence the deployment of natural prebiotic B-based nutraceuticals targeting the colon in the future. Our review is based on the discovery that MAB diet is absolutely necessary for healthy HMS in humans, by reversing DYS and restoring eubiosis for longer healthspan. | |
| 653 | |a Physiology | ||
| 653 | |a Fermentation | ||
| 653 | |a Telomerase | ||
| 653 | |a Flowers & plants | ||
| 653 | |a Life expectancy | ||
| 653 | |a Nutrition research | ||
| 653 | |a Health care | ||
| 653 | |a Aging | ||
| 653 | |a Colon | ||
| 653 | |a Bacteria | ||
| 653 | |a Microbiota | ||
| 653 | |a Prebiotics | ||
| 653 | |a Diet | ||
| 653 | |a Metabolism | ||
| 653 | |a Inflammation | ||
| 653 | |a Phenols | ||
| 653 | |a Metabolites | ||
| 653 | |a Oxidative stress | ||
| 700 | 1 | |a Scorei Ion Romulus |u Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., 31B Dunării Street, 207465 Podari, Romania; romulus_ion@yahoo.com | |
| 700 | 1 | |a Soriano-Ursúa, Marvin A |u Department of Physiology, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón, Mexico City 11340, Mexico; msoriano@ipn.mx | |
| 700 | 1 | |a Mogoşanu, George Dan |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 700 | 1 | |a Belu Ionela |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 700 | 1 | |a Ciocîlteu Maria Viorica |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 700 | 1 | |a Biţă, Cristina Elena |u Department of Rheumatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; cristina.gofita@umfcv.ro | |
| 700 | 1 | |a Rău Gabriela |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 700 | 1 | |a Pisoschi, Cătălina Gabriela |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 700 | 1 | |a Maria-Victoria, Racu |u <label>10</label>National Agency for Public Health, 67A Georghe Asachi Street, MD-2028 Chisinau, Moldova; maria-victoria.racu@ansp.gov.md (M.-V.R.); iurie.panzaru@ansp.gov.md (I.P.) | |
| 700 | 1 | |a Pinzaru Iurie |u <label>10</label>National Agency for Public Health, 67A Georghe Asachi Street, MD-2028 Chisinau, Moldova; maria-victoria.racu@ansp.gov.md (M.-V.R.); iurie.panzaru@ansp.gov.md (I.P.) | |
| 700 | 1 | |a Contreras-Ramos, Alejandra |u <label>11</label>Laboratory of Molecular Biology in the Congenital Malformations Unit, Children’s Hospital of Mexico Federico Gomez (HIMFG), Calle Dr. Marques 162, Col. Doctores, Alc. Cuahutémoc, Mexico City 06720, Mexico; acora_ramos@hotmail.com | |
| 700 | 1 | |a Kostici Roxana |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 700 | 1 | |a Neamţu Johny |u Drug Research Center, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; andreibita@gmail.com (A.B.); george.mogosanu@umfcv.ro (G.D.M.); maria.ciocilteu@umfcv.ro (M.V.C.); gabriela.rau@umfcv.ro (G.R.); catalina.pisoschi@umfcv.ro (C.G.P.); roxana.kostici@umfcv.ro (R.K.); johny.neamtu@umfcv.ro (J.N.) | |
| 700 | 1 | |a Biciuşcă Viorel |u <label>14</label>Department of Internal Medicine–Pneumology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; biciuscaviorel@gmail.com | |
| 700 | 1 | |a Gheonea, Dan Ionuţ |u <label>15</label>Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Romania; dan.gheonea@umfcv.ro | |
| 773 | 0 | |t Pharmaceuticals |g vol. 18, no. 6 (2025), p. 766-794 | |
| 786 | 0 | |d ProQuest |t Research Library | |
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