Photoautotrophic Production of Eicosapentaenoic Acid (EPA) with Nannochloropsis oceanica Under Dynamic Climate Simulations
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| Pubblicato in: | Processes vol. 13, no. 6 (2025), p. 1649-1666 |
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MDPI AG
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| Accesso online: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 045 | 2 | |b d20250101 |b d20251231 | |
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| 100 | 1 | |a Thurn Anna-Lena |u Chair of Biochemical Engineering, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany; annalena.thurn@tum.de (A.-L.T.); sebastian.gerwald@tum.de (S.G.) | |
| 245 | 1 | |a Photoautotrophic Production of Eicosapentaenoic Acid (EPA) with <i>Nannochloropsis oceanica</i> Under Dynamic Climate Simulations | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Marine microalgae from the genus Nannochloropsis are promising candidates for the photoautotrophic production of eicosapentaenoic acid (EPA, C20:5), a polyunsaturated fatty acid known for its numerous health benefits. A recent study demonstrated that Microchloropsis salina can accumulate high amounts of EPA when cultivated in flat-plate gas-lift photobioreactors. This study aimed to characterize an alternative strain, Nannochloropsis oceanica, and compare its biomass and EPA productivity to M. salina. Applying simulated dynamic climate conditions of a repeated sunny summer day in Eastern Australia, N. oceanica was cultivated in LED-illuminated flat-plate gas-lift photobioreactors. The results showed significantly higher biomass growth and EPA contents compared to M. salina. An EPA productivity of 33.0 ± 0.6 mgEPA L−1 d−1 has been achieved in batch processes with N. oceanica. Scaling up the photoautotrophic process to 8 m2 thin-layer cascade photobioreactors resulted in doubled concentrations of N. oceanica biomass compared to laboratory-scale batch processes. This improvement was likely due to the reduced fluid layer depth, which enhanced light availability to the microalgal cells. Using urea instead of nitrate as a nitrogen source further improved the EPA production of N. oceanica in thin-layer cascade photobioreactors, achieving CDW concentrations of up to 17.7 g L−1 and thus a high EPA concentration of 843 mg L−1. These findings highlight N. oceanica as an alternative to M. salina for sustainable EPA production, offering potential for further industrial applications. | |
| 651 | 4 | |a Germany | |
| 653 | |a Nitrates | ||
| 653 | |a Reactors | ||
| 653 | |a Eicosapentaenoic acid | ||
| 653 | |a Nitrogen | ||
| 653 | |a Biomass | ||
| 653 | |a Fish oils | ||
| 653 | |a Productivity | ||
| 653 | |a Polyunsaturated fatty acids | ||
| 653 | |a Photobioreactors | ||
| 653 | |a Algae | ||
| 653 | |a Lipids | ||
| 653 | |a Aquatic microorganisms | ||
| 653 | |a Batch processing | ||
| 653 | |a Simulation | ||
| 653 | |a Industrial applications | ||
| 653 | |a Batch processes | ||
| 653 | |a Omega-3 fatty acids | ||
| 653 | |a Carbon dioxide | ||
| 653 | |a Fishing | ||
| 653 | |a Light | ||
| 653 | |a Enzymes | ||
| 653 | |a Nannochloropsis oceanica | ||
| 700 | 1 | |a Gerwald Sebastian |u Chair of Biochemical Engineering, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany; annalena.thurn@tum.de (A.-L.T.); sebastian.gerwald@tum.de (S.G.) | |
| 700 | 1 | |a Brück, Thomas |u Werner Siemens-Chair of Synthetic Biotechnology, School of Natural Sciences, Technical University of Munich, 85748 Garching, Germany | |
| 700 | 1 | |a Weuster-Botz Dirk |u Chair of Biochemical Engineering, School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany; annalena.thurn@tum.de (A.-L.T.); sebastian.gerwald@tum.de (S.G.) | |
| 773 | 0 | |t Processes |g vol. 13, no. 6 (2025), p. 1649-1666 | |
| 786 | 0 | |d ProQuest |t Materials Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3223938940/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
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