Maternal gut microbiome interventions to improve maternal and perinatal health outcomes: Target product profile expert consensus and pipeline analysis
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| Vydáno v: | PLoS One vol. 20, no. 7 (Jul 2025), p. e0321543 |
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| Hlavní autor: | |
| Další autoři: | , , , , , , , , , |
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Public Library of Science
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| On-line přístup: | Citation/Abstract Full Text Full Text - PDF |
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MARC
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| 001 | 3226650883 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1932-6203 | ||
| 024 | 7 | |a 10.1371/journal.pone.0321543 |2 doi | |
| 035 | |a 3226650883 | ||
| 045 | 2 | |b d20250701 |b d20250731 | |
| 084 | |a 174835 |2 nlm | ||
| 100 | 1 | |a Mills, Kate | |
| 245 | 1 | |a Maternal gut microbiome interventions to improve maternal and perinatal health outcomes: Target product profile expert consensus and pipeline analysis | |
| 260 | |b Public Library of Science |c Jul 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a ObjectiveTo develop a novel Target Product Profile (TPP) outlining the minimum and optimal requirements of probiotics targeting the maternal gut microbiome, create a research and development (R&D) pipeline of maternal microbiome interventions, and identify the highest potential probiotic candidates matching TPP criteria.DesignA mixed-methods study including in-depth interviews, an international survey, and online public consultation, with systematic R&D pipeline development.SettingInternational research context in maternal gut microbiome interventions.PopulationTen stakeholder groups were included in the study for feedback on the TPP development.MethodsStakeholder feedback from 23 interviews and 32 survey responses was analyzed to revise the TPP. A systematic search of databases (Adis Insight, ClinicalTrials.gov, WHO ICTRP, Ovid MEDLINE, and relevant grant databases) identified drugs, supplements, and biologics targeting the maternal gut microbiome. Probiotic candidates were matched against key TPP criteria to identify promising options for future research.Main Outcome MeasuresStakeholder consensus (≥75% agreement) on TPP variables and identification of high-potential probiotic candidates.ResultsThe TPP met consensus for most of the 20 variables: 16 for minimum and 14 for optimal targets. Interviews raised issues concerning indication, target population, diagnostic requirements, and efficacy outcomes. Of 38 candidates identified in the maternal microbiome pipeline (2000–2023), eight were probiotics, with one high-potential candidate (Vivomixx) and two medium-potential candidates (Lactobacillus spp. and Bifidobacterium spp.) identified.ConclusionsThis study produced the first TPP and pipeline analysis for maternal gut microbiome interventions, identifying probiotics with higher potential. Few candidates reached late-phase research, highlighting the need for efficacy trials. | |
| 653 | |a Databases | ||
| 653 | |a Pathogens | ||
| 653 | |a Womens health | ||
| 653 | |a Probiotics | ||
| 653 | |a Feedback | ||
| 653 | |a Premature birth | ||
| 653 | |a Content analysis | ||
| 653 | |a Pregnancy | ||
| 653 | |a Dietary supplements | ||
| 653 | |a Research & development--R&D | ||
| 653 | |a Candidates | ||
| 653 | |a Drug development | ||
| 653 | |a Interviews | ||
| 653 | |a Microbiomes | ||
| 653 | |a Intestinal microflora | ||
| 653 | |a Gut microbiota | ||
| 653 | |a Effectiveness | ||
| 653 | |a Criteria | ||
| 653 | |a Variables | ||
| 653 | |a Surveys | ||
| 653 | |a Drug delivery | ||
| 653 | |a Stakeholders | ||
| 653 | |a Preeclampsia | ||
| 653 | |a Product development | ||
| 653 | |a Social | ||
| 700 | 1 | |a Tan, Joelle | |
| 700 | 1 | |a Guneratne, Tahlia | |
| 700 | 1 | |a Lindsay Keir | |
| 700 | 1 | |a Goldstein, Maya | |
| 700 | 1 | |a Ventola, Cécile | |
| 700 | 1 | |a Makama, Maureen | |
| 700 | 1 | |a Ammerdorffer, Anne | |
| 700 | 1 | |a Gülmezoglu, A Metin | |
| 700 | 1 | |a Vogel, Joshua P | |
| 700 | 1 | |a McDougall, Annie R A | |
| 773 | 0 | |t PLoS One |g vol. 20, no. 7 (Jul 2025), p. e0321543 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3226650883/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3226650883/fulltext/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3226650883/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |