Orai1 Expression and Vascular Function in Kidney Donors Determine Graft Outcomes at Short/Mid-Term
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| Pubblicato in: | Cells vol. 14, no. 13 (2025), p. 1005-1023 |
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| Altri autori: | , , , , , , , , , , , |
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MDPI AG
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| Accesso online: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 003 | UK-CbPIL | ||
| 022 | |a 2073-4409 | ||
| 024 | 7 | |a 10.3390/cells14131005 |2 doi | |
| 035 | |a 3229141820 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 231441 |2 nlm | ||
| 100 | 1 | |a García-Rojo, Esther |u Department of Urology, Hospital Universitario HM Sanchinarro, HM Hospitales, 28050 Madrid, Spain; esthergrojo@hotmail.com (E.G.-R.); jromerootero@hotmail.com (J.R.-O.) | |
| 245 | 1 | |a Orai1 Expression and Vascular Function in Kidney Donors Determine Graft Outcomes at Short/Mid-Term | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a We aimed to determine the influence of donors’ vascular function on renal function in recipients and to evaluate the role of Orai1 calcium channels as a potential marker. A prospective collaborative multicenter study was designed. Blood, aorta (HA), mesenteric arteries (HMAs) and corpus cavernosum (HCC) specimens were obtained from organ donors at the kidney procurement procedure (n = 60). Evolution (up to 2 years) of renal function measured as serum creatinine (SCr) and glomerular filtration rate (GFR) was evaluated in respective recipients (n = 64). Vascular responses were determined in HA, HMA and HCC from donors. Tumor necrosis factor-α, asymmetric dimethyl arginine and Orai1 were measured in plasma. Orai1 protein expression was also evaluated in each donor’s aorta. Endothelium-dependent vasodilation (HMA, HCC) and adrenergic contraction (HA) in donors determined renal function in recipients, 12 months post-transplantation. Donors in the best quartile of vascular function predicted lower SCr and higher GFR in kidney recipients for 12/24 months. Plasma Orai1 in donors was negatively correlated with vascular function and predicted renal function at 3–6 months post-transplantation. Donor Orai1 vascular content was associated with reduced vascular function and with poorer recipient renal function for 1-year post-transplantation. Systemic vascular function of kidney donors determines recipients’ renal function at short/mid-term. Donors’ vascular function and recipients’ renal function are negatively associated with donors’ Orai1 vascular expression, being a potential biomarker of renal outcomes. | |
| 651 | 4 | |a United States--US | |
| 653 | |a Glomerular filtration rate | ||
| 653 | |a Endothelium | ||
| 653 | |a Antibodies | ||
| 653 | |a Arteries | ||
| 653 | |a Orai1 protein | ||
| 653 | |a Aorta | ||
| 653 | |a Coronary vessels | ||
| 653 | |a Kidney diseases | ||
| 653 | |a Kidney transplantation | ||
| 653 | |a Renal function | ||
| 653 | |a Biomarkers | ||
| 653 | |a Tumor necrosis factor-TNF | ||
| 653 | |a Vasodilation | ||
| 653 | |a Kidney transplants | ||
| 653 | |a Calcium channels | ||
| 653 | |a Blood & organ donations | ||
| 653 | |a Organ donors | ||
| 653 | |a Brain death | ||
| 653 | |a Pathophysiology | ||
| 653 | |a Creatinine | ||
| 700 | 1 | |a Angulo, Javier |u Department of Histology-Research, Unidad de Investigación Traslacional en Cardiología (IRYCIS-UFV), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; alex.sevilleja9335@gmail.com (A.S.-O.); argentina.fernandez@salud.madrid.org (A.F.) | |
| 700 | 1 | |a El Assar Mariam |u Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain; melassar@iisgetafe.com (M.E.A.); leocadio.rodriguez@salud.madrid.org (L.R.-M.) | |
| 700 | 1 | |a Santos-Pérez de la Blanca Rocío |u Department of Urology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; rociosantosperez@hotmail.com (R.S.-P.d.l.B.); gendine@hotmail.com (B.G.-G.); josemedinapolo@movistar.es (J.M.-P.); arantolin@yahoo.es (A.R.-A.) | |
| 700 | 1 | |a García-Gómez Borja |u Department of Urology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; rociosantosperez@hotmail.com (R.S.-P.d.l.B.); gendine@hotmail.com (B.G.-G.); josemedinapolo@movistar.es (J.M.-P.); arantolin@yahoo.es (A.R.-A.) | |
| 700 | 1 | |a Medina-Polo, José |u Department of Urology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; rociosantosperez@hotmail.com (R.S.-P.d.l.B.); gendine@hotmail.com (B.G.-G.); josemedinapolo@movistar.es (J.M.-P.); arantolin@yahoo.es (A.R.-A.) | |
| 700 | 1 | |a Sevilleja-Ortiz Alejandro |u Department of Histology-Research, Unidad de Investigación Traslacional en Cardiología (IRYCIS-UFV), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; alex.sevilleja9335@gmail.com (A.S.-O.); argentina.fernandez@salud.madrid.org (A.F.) | |
| 700 | 1 | |a Rodríguez-Mañas Leocadio |u Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain; melassar@iisgetafe.com (M.E.A.); leocadio.rodriguez@salud.madrid.org (L.R.-M.) | |
| 700 | 1 | |a Fernández Argentina |u Department of Histology-Research, Unidad de Investigación Traslacional en Cardiología (IRYCIS-UFV), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; alex.sevilleja9335@gmail.com (A.S.-O.); argentina.fernandez@salud.madrid.org (A.F.) | |
| 700 | 1 | |a Gutiérrez-Martínez, Eduardo |u Department of Nephrology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; eduardogutmat90@gmail.com (E.G.-M.); emorales@senefro.org (E.M.-R.) | |
| 700 | 1 | |a Morales-Ruiz, Enrique |u Department of Nephrology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; eduardogutmat90@gmail.com (E.G.-M.); emorales@senefro.org (E.M.-R.) | |
| 700 | 1 | |a Rodríguez-Antolín, Alfredo |u Department of Urology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain; rociosantosperez@hotmail.com (R.S.-P.d.l.B.); gendine@hotmail.com (B.G.-G.); josemedinapolo@movistar.es (J.M.-P.); arantolin@yahoo.es (A.R.-A.) | |
| 700 | 1 | |a Romero-Otero, Javier |u Department of Urology, Hospital Universitario HM Sanchinarro, HM Hospitales, 28050 Madrid, Spain; esthergrojo@hotmail.com (E.G.-R.); jromerootero@hotmail.com (J.R.-O.) | |
| 773 | 0 | |t Cells |g vol. 14, no. 13 (2025), p. 1005-1023 | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3229141820/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3229141820/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3229141820/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |