Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory
Պահպանված է:
| Հրատարակված է: | Nature Communications vol. 16, no. 1 (2025), p. 6845 |
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| Հիմնական հեղինակ: | |
| Այլ հեղինակներ: | , , |
| Հրապարակվել է: |
Nature Publishing Group
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| Խորագրեր: | |
| Առցանց հասանելիություն: | Citation/Abstract Full Text Full Text - PDF |
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| 022 | |a 2041-1723 | ||
| 024 | 7 | |a 10.1038/s41467-025-61464-z |2 doi | |
| 035 | |a 3233395460 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 145839 |2 nlm | ||
| 100 | 1 | |a To, Tung V. |u UT Southwestern Medical Center, Department of Neurological Surgery, Dallas, USA (GRID:grid.267313.2) (ISNI:0000 0000 9482 7121) | |
| 245 | 1 | |a Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory | |
| 260 | |b Nature Publishing Group |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a In humans, the hippocampus exhibits evident structural and connectivity differences along the longitudinal axis. Experiments in rodents and more recently in human subjects have stimulated several theories of functional longitudinal specialization. This question pertains directly to the management of neurosurgical patients, as nascent technologies permit more precise treatments that can selectively spare longitudinal regions. With this in mind, we investigated hippocampal longitudinal specialization in 32 human intracranial EEG subjects as they performed an associative recognition episodic memory task. Utilizing the behavioral contrasts available in this task, we characterize the neurophysiological features that distinguish the anterior versus posterior hippocampal activity during recollection and familiarity–based memory retrieval, as well as novelty processing. We use subspace representations to characterize longitudinal differences in the temporal dynamics of key computational processes ascribed to the hippocampus, namely pattern separation and pattern completion. We place our findings in the context of existing models, adding to sparse literature using direct brain recordings to explicate the functional differentiation along the hippocampal longitudinal axis in humans.This study provides direct neurophysiological evidence from over 30 human subjects showing that the anterior and posterior hippocampus are functionally distinct, with differences in theta activity linked to recollection and novelty processing. | |
| 653 | |a Hippocampus | ||
| 653 | |a Differentiation | ||
| 653 | |a Memory tasks | ||
| 653 | |a Gene expression | ||
| 653 | |a Investigations | ||
| 653 | |a Neurosurgery | ||
| 653 | |a Associative memory | ||
| 653 | |a Electrodes | ||
| 653 | |a Novelty | ||
| 653 | |a Memory | ||
| 653 | |a Familiarity | ||
| 653 | |a Mental task performance | ||
| 653 | |a Paradigms | ||
| 653 | |a Amygdala | ||
| 653 | |a Neural networks | ||
| 653 | |a Episodic memory | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Wang, David X. |u UT Southwestern Medical Center, Department of Neurological Surgery, Dallas, USA (GRID:grid.267313.2) (ISNI:0000 0000 9482 7121) | |
| 700 | 1 | |a Wolfe, Cody B. |u UT Southwestern Medical Center, Department of Neurological Surgery, Dallas, USA (GRID:grid.267313.2) (ISNI:0000 0000 9482 7121) | |
| 700 | 1 | |a Lega, Bradley C. |u UT Southwestern Medical Center, Department of Neurological Surgery, Dallas, USA (GRID:grid.267313.2) (ISNI:0000 0000 9482 7121); UT Southwestern Medical Center, O’Donnell Brain Institute, Dallas, USA (GRID:grid.267313.2) (ISNI:0000 0000 9482 7121) | |
| 773 | 0 | |t Nature Communications |g vol. 16, no. 1 (2025), p. 6845 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3233395460/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3233395460/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3233395460/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |