Do Patients With Acute Coronary Syndrome Face Higher Mortality on Weekends Versus Weekdays? A Comprehensive Analysis of Demographic, Geographic, and Temporal Trends in the United States

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Publicado en:Clinical Cardiology vol. 48, no. 7 (Jul 1, 2025)
Autor principal: Shubietah, Abdalhakim
Otros Autores: Nazir, Abubakar, Elgendy, Mohamed S., Awashra, Ameer, Zeidalkilani, Jehad, Alqadi, Mohammad, Khreshi, Suleiman
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John Wiley & Sons, Inc.
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022 |a 1932-8737 
024 7 |a 10.1002/clc.70175  |2 doi 
035 |a 3233922346 
045 0 |b d20250701 
084 |a 162630  |2 nlm 
100 1 |a Shubietah, Abdalhakim  |u Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA 
245 1 |a Do Patients With Acute Coronary Syndrome Face Higher Mortality on Weekends Versus Weekdays? A Comprehensive Analysis of Demographic, Geographic, and Temporal Trends in the United States 
260 |b John Wiley & Sons, Inc.  |c Jul 1, 2025 
513 |a Journal Article 
520 3 |a ABSTRACT Background The impact of a “weekend effect” on US acute coronary syndrome (ACS) mortality remains uncertain. We compared weekend and weekday age‐adjusted mortality rates (AAMRs) and analyzed demographic, geographic, and temporal trends from 1999 to 2020. Methods We conducted a national analysis of ACS deaths (age ≥ 25 years) using CDC WONDER (ICD‐10: I20.0; I21.0–I21.4; I21.9; I22.0–I22.9; I24.8; I24.9). Crude and AAMRs (per 100 000; 2000 U.S. standard) were calculated, and trends were assessed by joinpoint regression to estimate annual percent changes (APCs) and average APCs (AAPCs). Results From 1999 to 2020, there were 3, 101, 451 ACS deaths: 2, 222, 468 on weekdays (AAMR 46.4; 95% CI 46.39–46.51) and 878, 983 on weekends (AAMR 18.4), a 2.5:1 ratio. Both periods saw two‐phase declines—APCs of ≈ –6.4%/year before 2009–2010 and –3.3 to –3.7%/year thereafter (all p <  0.001). Disparities persisted: Black adults had the highest AAMRs (20.9 weekend; 53.2 weekday), rural rates exceeded urban (28.7 vs. 15.8; 72.0 vs. 40.2), men exceeded women (23.8 vs. 14.0; 60.2 vs. 35.4), and rates rose steeply with age (weekend 0.3–223.0; weekday 0.7–561.0). After 2009, declines slowed, and weekday deaths in Black adults rose after 2018. Conclusions The weekend effect on ACS mortality is minimal, with weekday deaths far outnumbering weekend deaths. Persistent—and sometimes widening—disparities by race, rurality, sex, and age highlight the need for equity‐focused interventions, strengthened rural cardiac care, and targeted prevention. 
651 4 |a United States--US 
651 4 |a Alaska 
651 4 |a Arkansas 
653 |a Workforce planning 
653 |a Hispanic Americans 
653 |a Acute coronary syndromes 
653 |a Population 
653 |a Pacific Islander people 
653 |a Womens health 
653 |a Trends 
653 |a Mortality 
653 |a Native North Americans 
653 |a Hospitals 
653 |a Age groups 
653 |a Females 
653 |a Medical imaging 
653 |a Angina pectoris 
653 |a Disease control 
700 1 |a Nazir, Abubakar  |u Oli Health Magazine Organization, Kigali, Rwanda 
700 1 |a Elgendy, Mohamed S.  |u Faculty of Medicine, Tanta University, Tanta, Egypt 
700 1 |a Awashra, Ameer  |u Department of Medicine, An‐Najah National University, Nablus, West Bank, Palestine 
700 1 |a Zeidalkilani, Jehad  |u Department of Internal Medicine, MercyOne Siouxland Medical Center, Sioux City, Iowa, USA 
700 1 |a Alqadi, Mohammad  |u Department of Internal Medicine, University of Toledo, Toledo, Ohio, USA 
700 1 |a Khreshi, Suleiman  |u Department of Internal Medicine, St. Mary Medical Center, Trinity Health Mid‐Atlantic, Langhorne, Pennsylvania, USA 
773 0 |t Clinical Cardiology  |g vol. 48, no. 7 (Jul 1, 2025) 
786 0 |d ProQuest  |t Health & Medical Collection 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3233922346/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text  |u https://www.proquest.com/docview/3233922346/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text - PDF  |u https://www.proquest.com/docview/3233922346/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch