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Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging

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Publicado en:NPJ Aging vol. 11, no. 1 (2025), p. 73-87
Autor principal: Hall, Megan C.
Otros Autores: Rempe, Maggie P., Casagrande, Chloe C., Glesinger, Ryan J., Petro, Nathan M., Garrison, Grant M., John, Jason A., Dietz, Sarah M., Schantell, Mikki, Bai, Hua, Arif, Yasra, Embury, Christine M., Bashford, Seth, Okelberry, Hannah J., Petts, Aubrie J., Keifer, Elizabeth L., May-Weeks, Pamela E., Picci, Giorgia, Heinrichs-Graham, Elizabeth, Wilson, Tony W.
Publicado:
Nature Publishing Group
Materias:
Hispanic Americans
Segregation
Oscillations
Magnetoencephalography
Word processing
Hypotheses
Life span
Brain research
Aging
Information processing
Older people
Semantics
Preservation
Acceso en línea:Citation/Abstract
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022 |a 2056-3973 
024 7 |a 10.1038/s41514-025-00263-8  |2 doi 
035 |a 3237100374 
045 2 |b d20250101  |b d20251231 
084 |a 274863  |2 nlm 
100 1 |a Hall, Megan C.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
245 1 |a Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging 
260 |b Nature Publishing Group  |c 2025 
513 |a Journal Article 
520 3 |a Semantic processing remains relatively preserved during healthy aging, but the mechanisms are poorly understood. Herein, we use dynamic functional mapping based on magnetoencephalography to examine the neural oscillations serving semantic processing across the adult lifespan (N = 154; 21–87 years). Task-related oscillatory dynamics were imaged using a beamformer and whole-brain linear mixed-effects (LME) models were calculated with age and task condition (semantically-related or -unrelated) as factors. LMEs revealed significant age-by-condition interactions on alpha and beta activity in multiple regions, which generally reflected stronger responses with increasing age and/or in the semantically-related condition across regions (p values < 0.005, corrected). Follow-up mediation analyses of these interaction clusters indicated that left perisylvian alpha responses suppressed the effect of age on verbal fluency (p = 0.014), with larger conditional differences in this region supporting preserved fluency with increasing age. Our findings provide novel insight on age-related neurophysiological adaptations that support preservation of semantic processing. 
653 |a Hispanic Americans 
653 |a Segregation 
653 |a Oscillations 
653 |a Magnetoencephalography 
653 |a Word processing 
653 |a Hypotheses 
653 |a Life span 
653 |a Brain research 
653 |a Aging 
653 |a Information processing 
653 |a Older people 
653 |a Semantics 
653 |a Preservation 
700 1 |a Rempe, Maggie P.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586); College of Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE, USA (ROR: https://ror.org/00thqtb16) (GRID: grid.266813.8) (ISNI: 0000 0001 0666 4105) 
700 1 |a Casagrande, Chloe C.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Glesinger, Ryan J.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Petro, Nathan M.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Garrison, Grant M.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a John, Jason A.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Dietz, Sarah M.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Schantell, Mikki  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Bai, Hua  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Arif, Yasra  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Embury, Christine M.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Bashford, Seth  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Okelberry, Hannah J.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Petts, Aubrie J.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a Keifer, Elizabeth L.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586) 
700 1 |a May-Weeks, Pamela E.  |u College of Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE, USA (ROR: https://ror.org/00thqtb16) (GRID: grid.266813.8) (ISNI: 0000 0001 0666 4105) 
700 1 |a Picci, Giorgia  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586); Department of Pharmacology &amp;amp; Neuroscience, Creighton University, Omaha, NE, USA (ROR: https://ror.org/05wf30g94) (GRID: grid.254748.8) (ISNI: 0000 0004 1936 8876) 
700 1 |a Heinrichs-Graham, Elizabeth  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586); Department of Pharmacology &amp;amp; Neuroscience, Creighton University, Omaha, NE, USA (ROR: https://ror.org/05wf30g94) (GRID: grid.254748.8) (ISNI: 0000 0004 1936 8876) 
700 1 |a Wilson, Tony W.  |u Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA (ROR: https://ror.org/01q9r1072) (GRID: grid.414583.f) (ISNI: 0000 0000 8953 4586); College of Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE, USA (ROR: https://ror.org/00thqtb16) (GRID: grid.266813.8) (ISNI: 0000 0001 0666 4105); Department of Pharmacology &amp;amp; Neuroscience, Creighton University, Omaha, NE, USA (ROR: https://ror.org/05wf30g94) (GRID: grid.254748.8) (ISNI: 0000 0004 1936 8876) 
773 0 |t NPJ Aging  |g vol. 11, no. 1 (2025), p. 73-87 
786 0 |d ProQuest  |t Health & Medical Collection 
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