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Cardiac Function in Women with and Without Previous Assisted Reproductive Technology: A Prospective Observational Cohort Study

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Publicado en:Journal of Clinical Medicine vol. 14, no. 15 (2025), p. 5366-5378
Autor principal: Baird, Freya
Otros Autores: Kakouri Eleni, Huluta Iulia, Sarris Ippokratis, Sunkara, Sesh K, Nicolaides, Kypros H, Kametas Nick
Publicado:
MDPI AG
Materias:
United States > US
United Kingdom > UK
Doppler effect
Velocity
Diabetes
Software packages
Womens health
Body mass index
Blood pressure
Demographics
Hypertension
Cohort analysis
Pregnancy
Fertility
Reproductive technologies
Infertility
Liver diseases
Ultrasonic imaging
Cardiac function
Acceso en línea:Citation/Abstract
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Resumen:Background: Previous research has linked hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) with assisted reproductive technology (ART). It is not clear whether this reflects the background population cardiovascular profiles or whether ART independently increases the long-term risk for CVD and alters cardiovascular function. Furthermore, CVD has been associated with pathological cardiovascular function before and after the establishment of the disease. The aim of this study was to compare cardiac function in women attending for ART between those who had previous treatment and those who had not after controlling for demographic characteristics which have been shown to affect cardiovascular function. Methods: This was a prospective observational cohort study at a London fertility clinic. Women were consecutively enrolled between May 2021 and March 2022. Maternal demographics and cardiac function using transthoracic echocardiography were assessed before the current treatment cycle in the mid-luteal phase of the menstrual cycle. Maternal demographics included age, body mass index, smoking, race, and parity. Cardiovascular parameters included blood pressure and indices of left-ventricular systolic and diastolic function. Differences between cardiac variables after controlling for maternal demographics and history of previous ART were assessed by multivariate linear regression. Results: There were 232 healthy women who agreed to participate in the study; of those, 153 (58%) had undergone previous ART. After controlling for maternal demographic characteristics, previous assisted reproductive technology was not an independent predictor of cardiac function. Conclusions: Previous ART is not associated with significant changes in cardiac function.
ISSN:2077-0383
DOI:10.3390/jcm14155366
Fuente:Health & Medical Collection