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A Comparative Analysis of Usual- and Gastric-Type Cervical Adenocarcinoma in a Japanese Population Reveals Distinct Clinicopathological and Molecular Features with Prognostic and Therapeutic Insights

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Publicado en:International Journal of Molecular Sciences vol. 26, no. 15 (2025), p. 7469-7489
Autor principal: Zahan Umme Farzana
Otros Autores: Islam, Sohel Hasibul, Nakayama Kentaro, Ishikawa Masako, Nagase Mamiko, Sultana, Razia, Kanno Kosuke, Yamashita Hitomi, Begum, Sonia Shahataj, Kyo Satoru
Publicado:
MDPI AG
Materias:
Cervical cancer
Medical prognosis
Human papillomavirus
Mutation
Survival analysis
Lymphatic system
Acceso en línea:Citation/Abstract
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Resumen:Gastric-type cervical adenocarcinoma (GCA) is a rare and aggressive subtype of cervical adenocarcinoma. Despite its clinical significance, its molecular carcinogenesis and therapeutic targets remain poorly understood. This study aimed to compare the clinicopathological, immunohistochemical, and molecular profiles of GCA and usual-type cervical adenocarcinoma (UCA), exploring prognostic and therapeutic biomarkers in a Japanese population. A total of 110 cervical adenocarcinoma cases, including 16 GCA and 94 UCA cases, were retrospectively analyzed for clinicopathological features, and a panel of immunohistochemical markers was assessed. Sanger sequences were performed for the KRAS, PIK3CA, and BRAF genes, and survival and clinicopathological correlations were assessed using Kaplan–Meier and Cox regression analyses. GCA was significantly associated with more aggressive features than UCA, including lymph node involvement, advanced FIGO stages, increasing recurrence rate, and poor survival status. High ARID1B expression was observed in a subset of GCA cases and correlated with worse progression-free and overall survival. Additionally, PD-L1 expression was more frequent in GCA than UCA and was associated with unfavorable prognostic factors. Conversely, UCA cases showed strong p16 expression, supporting their HPV-driven pathogenesis. Molecular profiling revealed KRAS and PIK3CA mutations in both subtypes, while BRAF mutations were identified exclusively in GCA. These findings reveal distinct clinical and molecular profiles for both tumor types and underscore ARID1B and PD-L1 as predictive prognostic and therapeutic biomarkers in GCA, implicating the use of subtype-specific treatment strategies.
ISSN:1661-6596
1422-0067
DOI:10.3390/ijms26157469
Fuente:Health & Medical Collection