From Hue to Health: Exploring the Therapeutic Potential of Plant-Pigment-Enriched Extracts
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| Vydáno v: | Microorganisms vol. 13, no. 8 (2025), p. 1818-1846 |
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| Hlavní autor: | |
| Další autoři: | , , , , |
| Vydáno: |
MDPI AG
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| On-line přístup: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| Abstrakt: | The escalating global challenges of antimicrobial resistance (AMR) and cancer necessitate innovative therapeutic solutions from natural sources. This study investigated the multifaceted therapeutic potential of pigment-enriched plant extracts. We screened diverse plant extracts for antimicrobial and antibiofilm activity against multidrug-resistant bacteria and fungi. Hibiscus sabdariffa emerged as the most promising, demonstrating potent broad-spectrum antimicrobial and significant antibiofilm activity. Sub-inhibitory concentrations of H. sabdariffa robustly downregulated essential bacterial virulence genes and suppressed aflatoxin gene expression. Comprehensive chemical profiling via HPLC identified major anthocyanin glucosides, while GC-MS revealed diverse non-pigment bioactive compounds, including fatty acids and alcohols. Molecular docking suggested favorable interactions of key identified compounds (Cyanidin-3-O-glucoside and 1-Deoxy-d-arabitol) with E. coli outer membrane protein A (OmpA), indicating potential antiadhesive and antimicrobial mechanisms. Furthermore, H. sabdariffa exhibited selective cytotoxicity against MCF-7 breast cancer cells. These findings establish H. sabdariffa pigment-enriched extract as a highly promising, multi-functional source of novel therapeutics, highlighting its potential for simultaneously addressing drug resistance and cancer challenges through an integrated chemical, biological, and computational approach. |
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| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms13081818 |
| Zdroj: | Biological Science Database |