High‐Resolution Pharyngeal Manometry Assessment of Swallowing in Asymptomatic Myotonic Dystrophy
Guardado en:
| Udgivet i: | Laryngoscope Investigative Otolaryngology vol. 10, no. 4 (Aug 1, 2025) |
|---|---|
| Hovedforfatter: | |
| Andre forfattere: | , , |
| Udgivet: |
John Wiley & Sons, Inc.
|
| Fag: | |
| Online adgang: | Citation/Abstract Full Text Full Text - PDF |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|
MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3244609287 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2378-8038 | ||
| 024 | 7 | |a 10.1002/lio2.70209 |2 doi | |
| 035 | |a 3244609287 | ||
| 045 | 0 | |b d20250801 | |
| 100 | 1 | |a Asayama, Rie |u Department of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan | |
| 245 | 1 | |a High‐Resolution Pharyngeal Manometry Assessment of Swallowing in Asymptomatic Myotonic Dystrophy | |
| 260 | |b John Wiley & Sons, Inc. |c Aug 1, 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a ABSTRACT Objectives Myotonic dystrophy (MyD) adversely affects swallowing function from an early stage. However, the swallowing characteristics of patients with MyD, who rarely seek medical attention owing to a lack of subjective symptoms, remain unclear. We aimed to analyze multifaceted swallowing function tests, including high‐resolution manometry (HRM), in patients with asymptomatic MyD and evaluate the swallowing pathophysiology in these patients. Methods We included patients who underwent HRM and swallowing function tests, including videofluoroscopic swallow study (VFSS), at our hospital. We analyzed the results along with the clinical and demographic profiles of the patients, comparing them to those in a non‐MyD control group of patients with mild dysphagia. Results The MyD group demonstrated significantly decreased swallowing motility on VFSS and reduced pharyngeal contraction force at all stages from the pharynx to the upper esophageal sphincter (UES) on HRM. In the non‐MyD control group, a weak negative correlation was observed between maximum pharyngeal contraction force and minimum UES pressure during swallowing. Conversely, in the MyD group, the minimum UES pressure remained consistently low, regardless of weak pharyngeal contraction force. Conclusion Our study confirmed that patients with MyD exhibited significant motor disorders of swallowing‐related muscles even when unaware of their dysphagia. While constant UES relaxation may help maintain swallowing, particularly for liquids, it hinders patients' ability to recognize their swallowing problems and can lead to sudden choking episodes. Early risk management and intervention are, thus, necessary for patients with MyD, even those unaware of their dysphagia. Level of Evidence IV. | |
| 651 | 4 | |a United States--US | |
| 651 | 4 | |a Minneapolis Minnesota | |
| 653 | |a Patients | ||
| 653 | |a Quality of life | ||
| 653 | |a Software | ||
| 653 | |a Pneumonia | ||
| 653 | |a Body mass index | ||
| 653 | |a Age | ||
| 653 | |a Disease | ||
| 653 | |a Catheters | ||
| 653 | |a Ostomy | ||
| 653 | |a Esophagus | ||
| 653 | |a Swallowing | ||
| 653 | |a Dysphagia | ||
| 653 | |a Genotype & phenotype | ||
| 653 | |a Kinases | ||
| 653 | |a Pathophysiology | ||
| 700 | 1 | |a Tanaka‐Nishikubo, Kaori |u Department of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan | |
| 700 | 1 | |a Tanaka, Keiko |u Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan | |
| 700 | 1 | |a Hato, Naohito |u Department of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan | |
| 773 | 0 | |t Laryngoscope Investigative Otolaryngology |g vol. 10, no. 4 (Aug 1, 2025) | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3244609287/abstract/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3244609287/fulltext/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3244609287/fulltextPDF/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |