Molecular insights in potentiation of antibiotic activity by apple cider vinegar in diabetic wound pathogens
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| Publicat a: | Future Journal of Pharmaceutical Sciences vol. 11, no. 1 (Dec 2025), p. 117 |
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| Autor principal: | |
| Altres autors: | , , , , , |
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Springer Nature B.V.
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| Accés en línia: | Citation/Abstract Full Text Full Text - PDF |
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| 001 | 3246239497 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2314-7245 | ||
| 022 | |a 2314-7253 | ||
| 024 | 7 | |a 10.1186/s43094-025-00876-6 |2 doi | |
| 035 | |a 3246239497 | ||
| 045 | 2 | |b d20251201 |b d20251231 | |
| 100 | 1 | |a Mahanoor, Syeda |u Lahore University of Biological and Applied Sciences, Department of Basic Medical Sciences, Faculty of Pharmaceutical Sciences, Lahore, Pakistan (GRID:grid.440564.7) (ISNI:0000 0001 0415 4232); University of Veterinary and Animal Sciences, Department of Pharmacology and Toxicology, Lahore, Pakistan (GRID:grid.412967.f) (ISNI:0000 0004 0609 0799) | |
| 245 | 1 | |a Molecular insights in potentiation of antibiotic activity by apple cider vinegar in diabetic wound pathogens | |
| 260 | |b Springer Nature B.V. |c Dec 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a BackgroundThe prevalence of antibiotic resistance has become a critical global health concern. In particular, resistant strains of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) against commonly prescribed antibiotics for various infections are on the rise. These pathogens are frequently implicated in severe and complex infections, e.g., diabetic foot infections (DFI), posing a significant antimicrobial challenges during treatment. Frequently used food grade product, i.e., apple cider vinegar (ACV) carries promising antimicrobial potential. Therefore, the study designed to investigate the potential of ACV in combination with antibiotics to determine the effectiveness of the combination in overall pathogenic burden.ResultsAntimicrobial sensitivity was evaluated using disk diffusion and broth dilution techniques, revealing that at 2.5% acidity, ACV has prominent inhibitory potential against SA and PA. The fractional inhibitory concentration (FIC) index further confirmed synergistic interplay of ACV in combination with antibiotics. The results for minimum bactericidal concentration (MBC) showed when ACV is added to existing antibiotics the MBC value after checkerboard analysis method comes out to be, 128 µg/mL, 128 µg/mL, 64 µg/mL, and 64 µg/mL for amoxicillin, cefotaxime, imipenem, and vancomycin, respectively, against SA whereas concentration of 128 µg/mL, 256 µg/mL, 256 µg/mL, and 128 µg/mL MBC values for respective antibiotics against PA. Quantitative PCR analysis has demonstrated a substantial reduction in the expression of resistance-conferring genes when ACV was combined with antibiotics. Furthermore, molecular docking analysis showed ACV’s active constituents, such as acetic acid and chlorogenic acid, exhibited strong binding affinities against resistant conferring genes and subsequent proteins expression. These findings suggest that ACV may alter permeability of the outer membrane porin channels, thereby improving antibiotic penetration and augmented antimicrobial efficacy.ConclusionThe study demonstrated that ACV not only improves antibiotic permeability within bacterial cell but also significantly augments bactericidal activity of these agents against resistant strains of SA and PA. The combination of various concentrations of ACV with antibiotics presents an innovative therapeutic strategy to combat current antimicrobial resistance, particularly in the treatment and management of complex DFI. These findings underscore the potential of integrating food grade products with conventional antibiotics to address the growing challenges of antibiotic resistance. | |
| 651 | 4 | |a Lahore Pakistan | |
| 651 | 4 | |a Pakistan | |
| 653 | |a Leg ulcers | ||
| 653 | |a Immunosuppressive agents | ||
| 653 | |a Diabetes | ||
| 653 | |a Acids | ||
| 653 | |a Antibiotics | ||
| 653 | |a Foot diseases | ||
| 653 | |a Bacteria | ||
| 653 | |a Staphylococcus infections | ||
| 653 | |a Animal lactation | ||
| 653 | |a Antimicrobial agents | ||
| 653 | |a Vinegar | ||
| 653 | |a Toxicology | ||
| 653 | |a Penicillin | ||
| 653 | |a Animal sciences | ||
| 653 | |a Drug resistance | ||
| 653 | |a Consent | ||
| 700 | 1 | |a Ghauri, Mohsin Ahmad |u Lahore University of Biological and Applied Sciences, Department of Basic Medical Sciences, Faculty of Pharmaceutical Sciences, Lahore, Pakistan (GRID:grid.440564.7) (ISNI:0000 0001 0415 4232); Xi’an Jiaotong University, School of Pharmacy, Health Science Center, Shaanxi, China (GRID:grid.43169.39) (ISNI:0000 0001 0599 1243) | |
| 700 | 1 | |a Ahmad, Shakeel |u Lahore University of Biological and Applied Sciences, Department of Basic Medical Sciences, Faculty of Pharmaceutical Sciences, Lahore, Pakistan (GRID:grid.440564.7) (ISNI:0000 0001 0415 4232) | |
| 700 | 1 | |a Mahmood, Rabia |u Lahore University of Biological and Applied Sciences, Department of Basic Medical Sciences, Faculty of Pharmaceutical Sciences, Lahore, Pakistan (GRID:grid.440564.7) (ISNI:0000 0001 0415 4232) | |
| 700 | 1 | |a Shabbir, Muhammad Aqib |u Lahore University of Biological and Applied Sciences, Department of Biotechnology, Faculty of Biological Sciences, Lahore, Pakistan (GRID:grid.440564.7) (ISNI:0000 0001 0415 4232) | |
| 700 | 1 | |a Rasheed, Muhammad Adil |u University of Veterinary and Animal Sciences, Department of Pharmacology and Toxicology, Lahore, Pakistan (GRID:grid.412967.f) (ISNI:0000 0004 0609 0799) | |
| 700 | 1 | |a Omer, Muhammad Ovais |u University of Veterinary and Animal Sciences, Department of Pharmacology and Toxicology, Lahore, Pakistan (GRID:grid.412967.f) (ISNI:0000 0004 0609 0799) | |
| 773 | 0 | |t Future Journal of Pharmaceutical Sciences |g vol. 11, no. 1 (Dec 2025), p. 117 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3246239497/abstract/embedded/Q8Z64E4HU3OH5N8U?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3246239497/fulltext/embedded/Q8Z64E4HU3OH5N8U?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3246239497/fulltextPDF/embedded/Q8Z64E4HU3OH5N8U?source=fedsrch |