Identification of a novel aminoglycoside nucleotidyltransferase ANT(3″)-Ic from Citrobacter telavivum S24
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| Vydáno v: | BMC Microbiology vol. 25 (2025), p. 1-13 |
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| Hlavní autor: | |
| Další autoři: | , , , , , , |
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Springer Nature B.V.
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| On-line přístup: | Citation/Abstract Full Text Full Text - PDF |
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MARC
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| 001 | 3247132672 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1471-2180 | ||
| 024 | 7 | |a 10.1186/s12866-025-04282-z |2 doi | |
| 035 | |a 3247132672 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 58455 |2 nlm | ||
| 100 | 1 | |a Lu, Junwan | |
| 245 | 1 | |a Identification of a novel aminoglycoside nucleotidyltransferase ANT(3″)-Ic from <i>Citrobacter telavivum</i> S24 | |
| 260 | |b Springer Nature B.V. |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Understanding the antibiotic resistance profile of the emerging pathogen Citrobacter telavivum S24 is important for clinical care, surveillance, and research. C. telavivum S24, a strain that exhibits resistance to both streptomycin and spectinomycin, was isolated from the soil at a broiler chicken farm. The strain was identified by whole-genome sequencing and average nucleotide identity analyses. Annotation of the resistance genes revealed that a novel aminoglycoside resistance gene, designated ant(3″)-Ic, is located on the chromosome of C. telavivum S24. This gene exhibits 52% similarity with the previously functionally characterized resistance gene aadA23. It distinguishes itself from ant(3″)-Ia and ant(3″)-Ib genes, and represents an independent branch. The ant(3″)-Ic gene is recognized as an inherent resistance gene of C. telavivum within a conserved genetic environment. The product of the ant(3″)-Ic gene is the aminoglycoside nucleotidyltransferase ANT(3″)-Ic, which has a theoretical pI of 5.05 and a molecular mass of 29 kDa. ANT(3”)-Ic inactivates streptomycin and spectinomycin with the Km of 46.13 and 115.90 µM, respectively. The discovery of the novel antibiotic resistance gene ant(3″)-Ic and the functional characterization of ANT(3”)-Ic will facilitate more targeted surveillance and treatment strategies for preventing and controlling zoonotic pathogens of zoonotic diseases. | |
| 651 | 4 | |a Beijing China | |
| 651 | 4 | |a United States--US | |
| 651 | 4 | |a Shanghai China | |
| 651 | 4 | |a China | |
| 651 | 4 | |a California | |
| 651 | 4 | |a Japan | |
| 653 | |a Infections | ||
| 653 | |a Antibiotic resistance | ||
| 653 | |a Surveillance | ||
| 653 | |a Phylogenetics | ||
| 653 | |a Genes | ||
| 653 | |a Streptomycin | ||
| 653 | |a Zoonoses | ||
| 653 | |a Genomes | ||
| 653 | |a Antibiotics | ||
| 653 | |a E coli | ||
| 653 | |a Annotations | ||
| 653 | |a Drug resistance | ||
| 653 | |a Proteins | ||
| 653 | |a Pathogens | ||
| 653 | |a Plasmids | ||
| 653 | |a Spectinomycin | ||
| 653 | |a Nucleotides | ||
| 653 | |a Citrobacter | ||
| 653 | |a Gene sequencing | ||
| 653 | |a Aminoglycosides | ||
| 653 | |a Cloning | ||
| 653 | |a Aminoglycoside antibiotics | ||
| 653 | |a Glucose | ||
| 653 | |a Antimicrobial agents | ||
| 653 | |a Whole genome sequencing | ||
| 653 | |a Poultry farming | ||
| 653 | |a Enzymes | ||
| 653 | |a Poultry | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Zhu, Mei | |
| 700 | 1 | |a Ye, Jingzeng | |
| 700 | 1 | |a Xu, Leyao | |
| 700 | 1 | |a Song, Chunhan | |
| 700 | 1 | |a Li, Kewei | |
| 700 | 1 | |a Bao, Qiyu | |
| 700 | 1 | |a Lin, Xi | |
| 773 | 0 | |t BMC Microbiology |g vol. 25 (2025), p. 1-13 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3247132672/abstract/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3247132672/fulltext/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3247132672/fulltextPDF/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |