Magnolia figo Extract Induces Enamel Shade Recovery and Inhibits Porphyromonas gingivalis Biofilm Formation: An In Vitro, Dual-Action Natural Therapeutic Approach
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| Publicado en: | International Journal of Molecular Sciences vol. 26, no. 17 (2025), p. 8157-8175 |
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| Autor principal: | |
| Otros Autores: | , , , |
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MDPI AG
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| Acceso en línea: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 001 | 3249691930 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1661-6596 | ||
| 022 | |a 1422-0067 | ||
| 024 | 7 | |a 10.3390/ijms26178157 |2 doi | |
| 035 | |a 3249691930 | ||
| 045 | 2 | |b d20250901 |b d20250914 | |
| 084 | |a 231645 |2 nlm | ||
| 100 | 1 | |a Chun-Sheng, Kuo |u PhD Program for Health Science and Industry, China Medical University, Taichung 404328, Taiwan; u110310201@cmu.edu.tw (C.-S.K.); cwlin@mail.cmu.edu.tw (C.-W.L.) | |
| 245 | 1 | |a <i>Magnolia figo</i> Extract Induces Enamel Shade Recovery and Inhibits <i>Porphyromonas gingivalis</i> Biofilm Formation: An In Vitro, Dual-Action Natural Therapeutic Approach | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Dental enamel discoloration, extrinsic staining, and periodontal biofilms remain persistent challenges in oral health. This study explores the in vitro, dual-functional potential of Magnolia figo flower extract (FMO), a sesquiterpene-rich botanical active phytochemical ingredient (API), for aesthetic and antimicrobial oral applications. FTIR identified characteristic terpenoid and long-chain fatty acid functional groups, including β-elemene, γ-elemene, and caryophyllene oxide. Whitening efficacy on coffee-stained bovine enamel was quantified using CIELAB colorimetry. The 0.5% FMO treatment achieved ΔE* = 8.49, which was within the clinical perceptibility threshold and the optimal biocompatibility balance. SEM confirmed no demineralization on the enamel surface after immersion in 3.0% FMO for 12 h. Antimicrobial assays demonstrated inhibition of Porphyromonas gingivalis, with MIC and MBC values of 0.25% and 0.5%, respectively. Biofilm formation was reduced by over 50% at a 0.148% concentration. Cytocompatibility assays using HGF-1 cells with various concentrations of FMO showed reduced cell viability at higher concentrations. When exposed for 5 min (simulating daily oral care) or 2 h, 0.5% FMO exhibited greater biocompatibility with L929 cells compared to toothpaste and peroxide-based agents. These findings suggest that FMO may serve as a natural candidate for dual-function oral care; however, further in vivo and clinical investigations are needed to validate its potential use within oral care treatments. | |
| 653 | |a Pathogens | ||
| 653 | |a Dental enamel | ||
| 653 | |a Oral hygiene | ||
| 653 | |a Spectrum analysis | ||
| 653 | |a Biofilms | ||
| 653 | |a Disease | ||
| 653 | |a Phytochemicals | ||
| 653 | |a Morphology | ||
| 653 | |a Hydroxyapatite | ||
| 653 | |a Scanning electron microscopy | ||
| 700 | 1 | |a Cheng-Wen, Lin |u PhD Program for Health Science and Industry, China Medical University, Taichung 404328, Taiwan; u110310201@cmu.edu.tw (C.-S.K.); cwlin@mail.cmu.edu.tw (C.-W.L.) | |
| 700 | 1 | |a Yuan-Man, Hsu |u Department of Animal Science and Biotechnology, Tunghai University, Taichung 407224, Taiwan; yuanmh@thu.edu.tw | |
| 700 | 1 | |a Tsai Jen-Chieh |u School of Pharmacy, China Medical University, Taichung 406040, Taiwan; jenchieh@mail.cmu.edu.tw | |
| 700 | 1 | |a Dan-Jae, Lin |u School of Dentistry, College of Dentistry, China Medical University, Taichung 404328, Taiwan | |
| 773 | 0 | |t International Journal of Molecular Sciences |g vol. 26, no. 17 (2025), p. 8157-8175 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3249691930/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3249691930/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3249691930/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |