Thromboelastographic Assessment of Coagulation Profiles in Dogs with Cardiac Tumors and Their Relationship to Cardiac Function
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| Yayımlandı: | Animals vol. 15, no. 18 (2025), p. 2674-2693 |
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| Diğer Yazarlar: | , , , , , , |
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MDPI AG
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| Online Erişim: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 035 | |a 3254462147 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
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| 100 | 1 | |a Yilmaz Zeki |u Department of Internal Medicine, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey; zyilmaz@uludag.edu.tr (Z.Y.); vetpinarlevent@gmail.com (P.L.); didem.algann@gmail.com (D.A.); tugbavarlik777@gmail.com (T.V.) | |
| 245 | 1 | |a Thromboelastographic Assessment of Coagulation Profiles in Dogs with Cardiac Tumors and Their Relationship to Cardiac Function | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Cardiac tumors are rare and linked to high mortality rates in both human and veterinary medicine. Despite their clinical significance, the effects of these tumors on coagulation and cardiac function remain poorly understood. This retrospective study assessed coagulation profiles and echocardiographic parameters in 14 dogs with cardiac tumors compared to 10 healthy controls. Tumors were identified through echocardiography, with further confirmation by computed tomography/magnetic resonance imaging. Coagulation was evaluated using conventional tests (prothrombin time (PT) and activated partial thromboplastin time (aPTT)) and thromboelastography (TEG). The employed conventional coagulation tests and echocardiographic parameters showed no significant differences between the groups. However, TEG revealed a hypercoagulable state in the majority of tumor-bearing dogs (8 out of 14), characterized by shortened reaction and clot formation times, as well as an increased α-angle and coagulation index (p < 0.05–0.001). No significant correlations were found between TEG parameters and echocardiographic indices. This study is the first to demonstrate subclinical hemostatic alterations using TEG in dogs with cardiac neoplasia. The results support the utility of TEG as a more sensitive tool than conventional tests for detecting hypercoagulability, potentially guiding individualized anticoagulant strategies in affected dogs. | |
| 651 | 4 | |a Italy | |
| 651 | 4 | |a United States--US | |
| 651 | 4 | |a Norway | |
| 653 | |a Veterinary medicine | ||
| 653 | |a Tomography | ||
| 653 | |a Anticoagulants | ||
| 653 | |a Tumors | ||
| 653 | |a Viscoelasticity | ||
| 653 | |a Biochemistry | ||
| 653 | |a Cardiac function | ||
| 653 | |a Magnetic resonance imaging | ||
| 700 | 1 | |a Salci Hakan |u Department of Surgery, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey; hsalci@uludag.edu.tr | |
| 700 | 1 | |a Pınar, Levent |u Department of Internal Medicine, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey; zyilmaz@uludag.edu.tr (Z.Y.); vetpinarlevent@gmail.com (P.L.); didem.algann@gmail.com (D.A.); tugbavarlik777@gmail.com (T.V.) | |
| 700 | 1 | |a Algan Didem |u Department of Internal Medicine, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey; zyilmaz@uludag.edu.tr (Z.Y.); vetpinarlevent@gmail.com (P.L.); didem.algann@gmail.com (D.A.); tugbavarlik777@gmail.com (T.V.) | |
| 700 | 1 | |a Varlik Tuğba |u Department of Internal Medicine, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey; zyilmaz@uludag.edu.tr (Z.Y.); vetpinarlevent@gmail.com (P.L.); didem.algann@gmail.com (D.A.); tugbavarlik777@gmail.com (T.V.) | |
| 700 | 1 | |a Topçu, Mehmet Emre |u Department of Pathology, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey; mehmetemretopcu@uludag.edu.tr | |
| 700 | 1 | |a Tanaka Ryou |u Life Science, Hamebe Team, Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Tokyo 183-8538, Japan; ryo@vet.ne.jp | |
| 700 | 1 | |a Hamabe Lina |u Life Science, Hamebe Team, Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Tokyo 183-8538, Japan; ryo@vet.ne.jp | |
| 773 | 0 | |t Animals |g vol. 15, no. 18 (2025), p. 2674-2693 | |
| 786 | 0 | |d ProQuest |t Publicly Available Content Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3254462147/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3254462147/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3254462147/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |