NADES-Mediated Deposition of Potential Biomimetic Drug-Loaded Polypyrrole on Biomedical Ti20Zr5Ta2Ag
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| Publicado no: | Biomimetics vol. 10, no. 9 (2025), p. 568-590 |
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| Autor principal: | |
| Outros Autores: | , |
| Publicado em: |
MDPI AG
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| Acesso em linha: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3254472015 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2313-7673 | ||
| 024 | 7 | |a 10.3390/biomimetics10090568 |2 doi | |
| 035 | |a 3254472015 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 100 | 1 | |a Nartita Radu |u Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Splaiul Independentei Street, No. 313, 060042 Bucharest, Romania; radu_sorin.nartita@upb.ro (R.N.); ioana.demetrescu@upb.ro (I.D.) | |
| 245 | 1 | |a NADES-Mediated Deposition of Potential Biomimetic Drug-Loaded Polypyrrole on Biomedical Ti20Zr5Ta2Ag | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a A natural deep eutectic solvent (NADES)-based electropolymerization strategy was developed to deposit polypyrrole (PPy) and Naproxen-doped PPy films onto a biomedical Ti–20Zr–5Ta–2Ag high-entropy alloy. Using cyclic voltammetry, chronoamperometry, and chronopotentiometry, coatings were grown potentiostatically (1.2–1.6 V) or galvanostatically (0.5–1 mA) to fixed charge values (1.6–2.2 C). Surface morphology and composition were assessed by optical microscopy, SEM and FTIR, while wettability was quantified via static contact-angle measurements in simulated body fluid (SBF). Electrochemical performance in SBF was evaluated through open-circuit potential monitoring, potentiodynamic polarization, and electrochemical impedance spectroscopy. Drug-release kinetics were determined by UV–Vis spectrophotometry and analyzed using mathematical modelling. Compared to uncoated alloy, PPy and PPy–Naproxen coatings increased hydrophilicity (contact angles reduced from ~31° to <10°), and reduced corrosion current densities from 754 µA/cm2 to below 5.5 µA/cm2, with polarization resistances rising from 0.06 to up to 37.8 kΩ·cm2. Naproxen incorporation further enhanced barrier integrity (Rcoat up to 1.4 × 1011 Ω·cm2) and enabled sustained drug release (>90% over 8 days), with diffusion exponents indicating Fickian (n ≈ 0.51) and anomalous (n ≈ 0.67) transport for potentiostatic and galvanostatic coatings, respectively. These multifunctional PPy–Naproxen films combine robust corrosion protection with controlled therapeutic delivery, supporting their potential biomimetic role as smart coatings for next-generation implantable devices. | |
| 651 | 4 | |a United States--US | |
| 651 | 4 | |a France | |
| 653 | |a Polypyrroles | ||
| 653 | |a Mechanical properties | ||
| 653 | |a Polymers | ||
| 653 | |a Corrosion | ||
| 653 | |a Electrolytes | ||
| 653 | |a Transplants & implants | ||
| 653 | |a Electrodes | ||
| 653 | |a Oxidation | ||
| 653 | |a Microscopy | ||
| 653 | |a Spectroscopy | ||
| 653 | |a Coatings | ||
| 653 | |a Light microscopy | ||
| 653 | |a Spectrophotometry | ||
| 653 | |a Voltammetry | ||
| 653 | |a Polarization | ||
| 653 | |a Alloys | ||
| 653 | |a Mathematical models | ||
| 653 | |a Morphology | ||
| 653 | |a Naproxen | ||
| 700 | 1 | |a Golgovici Florentina |u Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Splaiul Independentei Street, No. 313, 060042 Bucharest, Romania; radu_sorin.nartita@upb.ro (R.N.); ioana.demetrescu@upb.ro (I.D.) | |
| 700 | 1 | |a Demetrescu Ioana |u Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Splaiul Independentei Street, No. 313, 060042 Bucharest, Romania; radu_sorin.nartita@upb.ro (R.N.); ioana.demetrescu@upb.ro (I.D.) | |
| 773 | 0 | |t Biomimetics |g vol. 10, no. 9 (2025), p. 568-590 | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3254472015/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3254472015/fulltextwithgraphics/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3254472015/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |