Recent Advances in 3D Bioprinting of Porous Scaffolds for Tissue Engineering: A Narrative and Critical Review
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| 出版年: | Journal of Functional Biomaterials vol. 16, no. 9 (2025), p. 328-357 |
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| 第一著者: | |
| その他の著者: | , , , |
| 出版事項: |
MDPI AG
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| 主題: | |
| オンライン･アクセス: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 045 | 2 | |b d20250901 |b d20250930 | |
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| 100 | 1 | |a Picado-Tejero, David |u Departamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Avenida de Elvas, s/n, 06006 Badajoz, Spain; davidpicateje@unex.es (D.P.-T.); lmencer@unex.es (L.M.-C.); jpcarrasco@unex.es (J.P.C.-A.); acmarcos@unex.es (A.C.M.-R.) | |
| 245 | 1 | |a Recent Advances in 3D Bioprinting of Porous Scaffolds for Tissue Engineering: A Narrative and Critical Review | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a 3D bioprinting has emerged as a key tool in tissue engineering by facilitating the creation of customized scaffolds with properties tailored to specific needs. Among the design parameters, porosity stands out as a determining factor, as it directly influences critical mechanical and biological properties such as nutrient diffusion, cell adhesion and structural integrity. This review comprehensively analyses the state of the art in scaffold design, emphasizing how porosity-related parameters such as pore size, geometry, distribution and interconnectivity affect cellular behavior and mechanical performance. It also addresses advances in manufacturing methods, such as additive manufacturing and computer-aided design (CAD), which allow the development of scaffolds with hierarchical structures and controlled porosity. In addition, the use of computational modelling, in particular finite element analysis (FEA), as an essential predictive tool to optimize the design of scaffolds under physiological conditions is highlighted. This narrative review analyzed 112 core articles retrieved primarily from Scopus (2014–2025) to provide a comprehensive and up-to-date synthesis. Despite recent progress, significant challenges persist, including the lack of standardized methodologies for characterizing and comparing porosity parameters across different studies. This review identifies these gaps and suggests future research directions, such as the development of unified characterization and classification systems and the enhancement of nanoscale resolution in bioprinting technologies. By integrating structural design with biological functionality, this review underscores the transformative potential of porosity research applied to 3D bioprinting, positioning it as a key strategy to meet current clinical needs in tissue engineering. | |
| 653 | |a Tissue engineering | ||
| 653 | |a Biocompatibility | ||
| 653 | |a Mechanical properties | ||
| 653 | |a Finite element method | ||
| 653 | |a Structural engineering | ||
| 653 | |a Classification systems | ||
| 653 | |a Trends | ||
| 653 | |a Extracellular matrix | ||
| 653 | |a Biological properties | ||
| 653 | |a Structural design | ||
| 653 | |a Three dimensional printing | ||
| 653 | |a Manufacturing | ||
| 653 | |a Design | ||
| 653 | |a Cell adhesion | ||
| 653 | |a Additive manufacturing | ||
| 653 | |a Polymers | ||
| 653 | |a Parameter identification | ||
| 653 | |a Porosity | ||
| 653 | |a Cell adhesion & migration | ||
| 653 | |a Structural integrity | ||
| 653 | |a 3-D printers | ||
| 653 | |a Pore size | ||
| 653 | |a Pore size distribution | ||
| 653 | |a Computer aided design--CAD | ||
| 653 | |a Molecular structure | ||
| 653 | |a Scaffolds | ||
| 653 | |a Design optimization | ||
| 653 | |a Design parameters | ||
| 653 | |a Geometry | ||
| 653 | |a Morphology | ||
| 653 | |a Production methods | ||
| 653 | |a Hydrogels | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Mendoza-Cerezo, Laura |u Departamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Avenida de Elvas, s/n, 06006 Badajoz, Spain; davidpicateje@unex.es (D.P.-T.); lmencer@unex.es (L.M.-C.); jpcarrasco@unex.es (J.P.C.-A.); acmarcos@unex.es (A.C.M.-R.) | |
| 700 | 1 | |a Rodríguez-Rego, Jesús M |u Departamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Avenida de Elvas, s/n, 06006 Badajoz, Spain; davidpicateje@unex.es (D.P.-T.); lmencer@unex.es (L.M.-C.); jpcarrasco@unex.es (J.P.C.-A.); acmarcos@unex.es (A.C.M.-R.) | |
| 700 | 1 | |a Carrasco-Amador, Juan P |u Departamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Avenida de Elvas, s/n, 06006 Badajoz, Spain; davidpicateje@unex.es (D.P.-T.); lmencer@unex.es (L.M.-C.); jpcarrasco@unex.es (J.P.C.-A.); acmarcos@unex.es (A.C.M.-R.) | |
| 700 | 1 | |a Marcos-Romero, Alfonso C |u Departamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Avenida de Elvas, s/n, 06006 Badajoz, Spain; davidpicateje@unex.es (D.P.-T.); lmencer@unex.es (L.M.-C.); jpcarrasco@unex.es (J.P.C.-A.); acmarcos@unex.es (A.C.M.-R.) | |
| 773 | 0 | |t Journal of Functional Biomaterials |g vol. 16, no. 9 (2025), p. 328-357 | |
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