Human Microbiome as an Immunoregulatory Axis: Mechanisms, Dysbiosis, and Therapeutic Modulation
Shranjeno v:
| izdano v: | Microorganisms vol. 13, no. 9 (2025), p. 2147-2180 |
|---|---|
| Glavni avtor: | |
| Drugi avtorji: | , , , , , , , |
| Izdano: |
MDPI AG
|
| Teme: | |
| Online dostop: | Citation/Abstract Full Text Full Text - PDF |
| Oznake: |
Brez oznak, prvi označite!
|
MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3254605694 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2076-2607 | ||
| 024 | 7 | |a 10.3390/microorganisms13092147 |2 doi | |
| 035 | |a 3254605694 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 231538 |2 nlm | ||
| 100 | 1 | |a Cortés Matías |u Carrera de Biotecnología, Universidad de La Frontera, Temuco 4811230, Chile; m.cortes10@ufromail.cl (M.C.); p.olate02@ufromail.cl (P.O.) | |
| 245 | 1 | |a Human Microbiome as an Immunoregulatory Axis: Mechanisms, Dysbiosis, and Therapeutic Modulation | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a The human microbiome plays a central role in modulating the immune system and maintaining immunophysiological homeostasis, contributing to the prevention of immune-mediated diseases. In particular, the gut microbiota is a key ecosystem for immune system maturation, especially in early life. This review aimed to analyze the molecular and cellular mechanisms linking the microbiome to immune and neuronal functions, as well as the impact of dysbiosis and emerging therapeutic strategies targeting the microbiome. The analysis was based on scientific databases, prioritizing studies published since 2000, with special emphasis on the past decade. The microbiome influences immune signaling through microorganism-associated molecular patterns (MAMPs) and pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). Additionally, microbial metabolites—such as short-chain fatty acids (SCFAs), tryptophan derivatives, and secondary bile acids—exert significant immunomodulatory effects. The intestinal epithelial barrier is also described as an active immunological interface contributing to systemic regulation. The literature highlights innovative therapies, including fecal microbiota transplantation (FMT), probiotics, and microbiome editing with CRISPR-Cas technologies. These strategies aim to restore microbial balance and improve immune outcomes. The growing body of evidence positions the microbiome as a valuable clinical and diagnostic target, with significant potential for application in personalized medicine. | |
| 653 | |a Physiology | ||
| 653 | |a Transplants | ||
| 653 | |a Toll-like receptors | ||
| 653 | |a Probiotics | ||
| 653 | |a Immunoregulation | ||
| 653 | |a CRISPR | ||
| 653 | |a Immune system | ||
| 653 | |a Brain research | ||
| 653 | |a Homeostasis | ||
| 653 | |a Prebiotics | ||
| 653 | |a Diet | ||
| 653 | |a Gastrointestinal tract | ||
| 653 | |a Skin | ||
| 653 | |a Bile acids | ||
| 653 | |a Metabolites | ||
| 653 | |a Metabolism | ||
| 653 | |a Inflammation | ||
| 653 | |a Pattern recognition | ||
| 653 | |a Microbiomes | ||
| 653 | |a Tryptophan | ||
| 653 | |a Microorganisms | ||
| 653 | |a Feces | ||
| 653 | |a Autoimmune diseases | ||
| 653 | |a Antibiotics | ||
| 653 | |a Dysbacteriosis | ||
| 653 | |a Digestive system | ||
| 653 | |a Fecal microflora | ||
| 653 | |a Urogenital system | ||
| 653 | |a Pathogens | ||
| 653 | |a Diabetes | ||
| 653 | |a Precision medicine | ||
| 653 | |a Microbiota | ||
| 653 | |a Immunology | ||
| 653 | |a Chronic illnesses | ||
| 653 | |a Immunomodulation | ||
| 653 | |a Customization | ||
| 653 | |a Intestine | ||
| 653 | |a Intestinal microflora | ||
| 653 | |a Immunity (Disease) | ||
| 653 | |a Gut microbiota | ||
| 653 | |a Pattern recognition receptors | ||
| 653 | |a Well being | ||
| 700 | 1 | |a Olate, Paula |u Carrera de Biotecnología, Universidad de La Frontera, Temuco 4811230, Chile; m.cortes10@ufromail.cl (M.C.); p.olate02@ufromail.cl (P.O.) | |
| 700 | 1 | |a Rodriguez, Rodrigo |u Biocontrol Research Laboratory, Universidad de La Frontera, Temuco 4811230, Chile; r.rodriguez09@ufromail.cl | |
| 700 | 1 | |a Diaz Rommy |u Centro de Tecnología e Innovación de La Carne, Universidad de la Frontera, Temuco 4780000, Chile; rommy.diaz@ufrontera.cl (R.D.); a.martinez26@ufromail.cl (A.M.); nestor.sepulveda@ufrontera.cl (N.S.) | |
| 700 | 1 | |a Martínez Ailín |u Centro de Tecnología e Innovación de La Carne, Universidad de la Frontera, Temuco 4780000, Chile; rommy.diaz@ufrontera.cl (R.D.); a.martinez26@ufromail.cl (A.M.); nestor.sepulveda@ufrontera.cl (N.S.) | |
| 700 | 1 | |a Hernández Genisley |u Facultad de Ciencias Agropecuarias y Medioambiente, Universidad de La Frontera, Temuco 4780000, Chile; genisleyh@gmail.com | |
| 700 | 1 | |a Sepulveda Nestor |u Centro de Tecnología e Innovación de La Carne, Universidad de la Frontera, Temuco 4780000, Chile; rommy.diaz@ufrontera.cl (R.D.); a.martinez26@ufromail.cl (A.M.); nestor.sepulveda@ufrontera.cl (N.S.) | |
| 700 | 1 | |a Paz, Erwin A |u UWA Institute of Agriculture, The University of Western Australia, Perth 6009, Australia; erwin.pazmunoz@uwa.edu.au | |
| 700 | 1 | |a Quiñones, John |u Centro de Tecnología e Innovación de La Carne, Universidad de la Frontera, Temuco 4780000, Chile; rommy.diaz@ufrontera.cl (R.D.); a.martinez26@ufromail.cl (A.M.); nestor.sepulveda@ufrontera.cl (N.S.) | |
| 773 | 0 | |t Microorganisms |g vol. 13, no. 9 (2025), p. 2147-2180 | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3254605694/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3254605694/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3254605694/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |