תמונות העטיפה

The protective role of γδ T cells in endometrial cancer

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הוצא לאור ב:Cancer Immunology, Immunotherapy vol. 74, no. 10 (Oct 2025), p. 318
מחבר ראשי: Mysona, David P.
מחברים אחרים: Shah, Akash, Jaeger, Natalia, Almadadi, Ahmad, Orr, Brian, McIndoe, Richard, Johnson, Marian, Higgins, Robert, Rungruang, Bunja, Ghamande, Sharad, Hedrick, Catherine, Ley, Klaus
יצא לאור:
Springer Nature B.V.
נושאים:
T cell receptors
Cytotoxicity
Lipids
Transcriptomes
Infiltration
Microsatellite instability
Immunotherapy
Immune checkpoint inhibitors
Lymphocytes T
Uterine cancer
Lymphocytes
Amino acids
Major histocompatibility complex
Genomes
Endometrium
DNA-directed DNA polymerase
Endometrial cancer
Antigens
Microenvironments
Tumors
Exonuclease
Genes
גישה מקוונת:Citation/Abstract
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Resumen:Γδ T cells are non-conventional T cells that are not MHC restricted and have T cell receptors (TCRs) that are stimulated by phosphoantigens, stress-induced proteins, lipids, and other antigens. These cells are prognostic across cancer types in The Cancer Genome Atlas (TCGA) but have not been well studied in endometrial cancer, which has a rising incidence and mortality rate. Endometrial cancer patients have variable responses to checkpoint inhibitors which are related to the molecular subtype of their cancer. As such, there is a pressing need to understand the immune microenvironment in endometrial cancer. This study addresses this gap in knowledge by investigating γδ T cell repertoires and transcriptomes in this disease site. γδ T cell repertoires were obtained for 543 endometrial cancer patients within the TCGA and from 5 endometrial cancer patients in the single cell dataset SRP349751 using TRUST4. GLIPH2 was used to identify TCRs predicted to bind the same antigen. Transcriptomes were investigated in the single cell dataset. DNA Polymerase Epsilon Exonuclease (POLE) and Microsatellite Instability High (MSI-H) endometrial cancer subtypes had the most γδ T cell infiltration. Vδ1 and Vδ3 γδ T cell infiltration was prognostic independent of stage and molecular subtype. GLIPH2 analysis revealed TCRδ motifs for TDK, YTD, and GEL were public across all four molecular subtypes and were present in the single cell data set. Vδ1 γδ T cell transcriptomes were associated with cytotoxicity and recent TCR stimulation. These data support further investigation of immunotherapies targeting γδ T cells in endometrial cancer.
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-025-04177-y
Fuente:Health & Medical Collection