Non-malarial etiology of acute febrile episodes in children attending five healthcare facilities in Mwanza, Tanzania years 2020–2021
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| Publicado en: | Scientific Reports (Nature Publisher Group) vol. 15, no. 1 (2025), p. 34333-34347 |
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| 022 | |a 2045-2322 | ||
| 024 | 7 | |a 10.1038/s41598-025-16723-w |2 doi | |
| 035 | |a 3256604840 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
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| 100 | 1 | |a Kayange, Neema M. |u Department of Pediatrics, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania (ROR: https://ror.org/015qmyq14) (GRID: grid.411961.a) (ISNI: 0000 0004 0451 3858); Department of Pediatric and Child Health, Bugando Medical Centre, Mwanza, Tanzania (ROR: https://ror.org/05h7pem82) (GRID: grid.413123.6) (ISNI: 0000 0004 0455 9733) | |
| 245 | 1 | |a Non-malarial etiology of acute febrile episodes in children attending five healthcare facilities in Mwanza, Tanzania years 2020–2021 | |
| 260 | |b Nature Publishing Group |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Acute febrile illness (AFI) is a common cause of pediatric hospital visits in developing countries. Identifying the broad range of pathogens that can cause fever is critical to: improving AFI management, preventing unnecessary prescriptions, and guiding public health interventions. Between March 2020 and December 2021, 436 children in Mwanza, Tanzania were enrolled with acute fever lasting < 7 days. Malaria MRDT and microscopy, dengue rapid NSI antigen, dengue serology, chikungunya serology, urinalysis, blood and urine cultures were conducted. Multiplex reverse-transcriptase-polymerase-chain-reaction-ELISAs (m-RT-PCR-ELISA) were also performed for malaria, dengue virus type 1–4, Zika virus, chikungunya virus, yellow fever virus, Rift Valley fever virus, and West Nile virus. Nasopharyngeal swabs obtained from 77 children were used to identify respiratory pathogens using a multiplex PCR panel. Bacteria or viruses in the bloodstream, urinary and upper respiratory tracts were identified in 26/436 (6%), 47/436 (10.8%), and 33/77 (43%) of the participants, respectively. Pneumonia was diagnosed in 59/436 cases and confirmed in 8 by chest X-ray. The majority of isolates recovered from the bloodstream and upper respiratory tract were resistant to antibiotics commonly used clinically. Those organisms were most commonly found in cases of AFI. To conclude, there is an urgent need for point-of-care diagnostic assays for AFI that strengthen existing infection prevention interventions and evidence-based antimicrobial stewardship programs. | |
| 651 | 4 | |a Germany | |
| 651 | 4 | |a Tanzania | |
| 651 | 4 | |a Lake Victoria | |
| 653 | |a Chikungunya virus | ||
| 653 | |a Health promotion | ||
| 653 | |a Pathogens | ||
| 653 | |a Public health | ||
| 653 | |a Zika virus | ||
| 653 | |a Epidemiology | ||
| 653 | |a Laboratories | ||
| 653 | |a Influenza | ||
| 653 | |a Urine | ||
| 653 | |a Polymerase chain reaction | ||
| 653 | |a Serology | ||
| 653 | |a Health facilities | ||
| 653 | |a Respiratory tract | ||
| 653 | |a Developing countries--LDCs | ||
| 653 | |a Enzyme-linked immunosorbent assay | ||
| 653 | |a Pediatrics | ||
| 653 | |a Climate change | ||
| 653 | |a Malaria | ||
| 653 | |a Dengue fever | ||
| 653 | |a Respiratory diseases | ||
| 653 | |a Children | ||
| 653 | |a Antibiotics | ||
| 653 | |a West Nile virus | ||
| 653 | |a Hospitals | ||
| 653 | |a Antimicrobial agents | ||
| 653 | |a Immunoglobulins | ||
| 653 | |a Vector-borne diseases | ||
| 653 | |a Viral infections | ||
| 653 | |a Coccidioidomycosis | ||
| 653 | |a Rift Valley fever | ||
| 653 | |a Tropical diseases | ||
| 653 | |a Urinalysis | ||
| 653 | |a Social | ||
| 700 | 1 | |a Malande, Oliver Ombeva |u East Africa Centre for Vaccines and Immunization (ECAVI), Kampala, Uganda; Department of Pediatrics &amp; Child Health, Makerere University, Kampala, Uganda (ROR: https://ror.org/03dmz0111) (GRID: grid.11194.3c) (ISNI: 0000 0004 0620 0548); Department of Pediatrics &amp; Child Health, Moi University, Eldoret, Kenya (ROR: https://ror.org/04p6eac84) (GRID: grid.79730.3a) (ISNI: 0000 0001 0495 4256); Department of Public Health Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa (ROR: https://ror.org/003hsr719) (GRID: grid.459957.3) (ISNI: 0000 0000 8637 3780) | |
| 700 | 1 | |a Scialaba, Silvia |u Department of Pediatrics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (ROR: https://ror.org/00q1fsf04) (GRID: grid.410607.4) | |
| 700 | 1 | |a Gehring, Stephan |u Department of Pediatrics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (ROR: https://ror.org/00q1fsf04) (GRID: grid.410607.4) | |
| 700 | 1 | |a Groendahl, Britta |u Department of Pediatrics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (ROR: https://ror.org/00q1fsf04) (GRID: grid.410607.4) | |
| 700 | 1 | |a Koliopoulos, Philip |u Department of Pediatrics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (ROR: https://ror.org/00q1fsf04) (GRID: grid.410607.4) | |
| 700 | 1 | |a Mshana, Stephen E. |u Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania (ROR: https://ror.org/015qmyq14) (GRID: grid.411961.a) (ISNI: 0000 0004 0451 3858) | |
| 773 | 0 | |t Scientific Reports (Nature Publisher Group) |g vol. 15, no. 1 (2025), p. 34333-34347 | |
| 786 | 0 | |d ProQuest |t Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3256604840/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
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