Sedative potential of palmatine chloride in thiopental sodium-induced chicks: evidence from in vivo and in Silico studies
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| Veröffentlicht in: | Scientific Reports (Nature Publisher Group) vol. 15, no. 1 (2025), p. 34307-34317 |
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| 024 | 7 | |a 10.1038/s41598-025-19703-2 |2 doi | |
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| 100 | 1 | |a Nun, Feroz Khan |u Department of Pharmacy, Gopalganj Science and Technology University, 8100, Gopalganj, Bangladesh (ROR: https://ror.org/011xjpe74) (GRID: grid.449329.1) (ISNI: 0000 0004 4683 9733) | |
| 245 | 1 | |a Sedative potential of palmatine chloride in thiopental sodium-induced chicks: evidence from in vivo and in Silico studies | |
| 260 | |b Nature Publishing Group |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a The aim of this study is to assess the sedative impact of palmatine chloride (PME) in thiopental sodium-induced sleeping chicks and its underlying molecular mechanism by using in vivo and in silico approaches. Chicks received PME per orally (p.o.) at doses of 1.25, 2.5, and 5 mg/kg per body weight (b.w.), while diazepam (DZP) (2 mg/kg) served as a positive control and vehicle as a negative control. For the purpose of evaluating the experimental compounds synergistic or antagonistic effects, a combination of PME and DZP was administered to the chicks. After thirty minutes, thiopental sodium (40 mg/kg, intraperitoneal (i.p.)) was administered to induce sleep, and latency to sleep onset and sleep duration were measured. In vivo results showed that PME reduced sleep latency and prolonged sleep duration in a dose-dependent manner, with the combination therapy producing a significant enhancement of these effects. In silico docking revealed PME binding to gamma-aminobutyric acid A (GABAA) receptor α1 and β2 subunits (–7.2 kcal/mol) with shared amino acids. Pharmacokinetic and toxicity analyses suggested favorable drug-like properties. These results indicate PME’s sedative potential, alone or with DZP, likely via GABAergic modulation, warranting further functional validation. | |
| 651 | 4 | |a Bangladesh | |
| 651 | 4 | |a United States--US | |
| 653 | |a Sleep | ||
| 653 | |a Investigations | ||
| 653 | |a γ-Aminobutyric acid | ||
| 653 | |a Toxicity | ||
| 653 | |a Molecular modelling | ||
| 653 | |a Neurosciences | ||
| 653 | |a Sodium | ||
| 653 | |a Juveniles | ||
| 653 | |a Diazepam | ||
| 653 | |a γ-Aminobutyric acid A receptors | ||
| 653 | |a Body weight | ||
| 653 | |a Drug dosages | ||
| 653 | |a Chloride | ||
| 653 | |a Pharmacokinetics | ||
| 653 | |a Thiopental | ||
| 653 | |a Nervous system | ||
| 653 | |a Latency | ||
| 653 | |a Animal cognition | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Alshahrani, Mohammad Y. |u Central labs, King Khalid University, P.O. Box 61413, 9088, Abha, Saudi Arabia (ROR: https://ror.org/052kwzs30) (GRID: grid.412144.6) (ISNI: 0000 0004 1790 7100); Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, 9088, Abha, Saudi Arabia (ROR: https://ror.org/052kwzs30) (GRID: grid.412144.6) (ISNI: 0000 0004 1790 7100) | |
| 700 | 1 | |a Al Hasan, Md. Sakib |u Department of Pharmacy, Gopalganj Science and Technology University, 8100, Gopalganj, Bangladesh (ROR: https://ror.org/011xjpe74) (GRID: grid.449329.1) (ISNI: 0000 0004 4683 9733) | |
| 700 | 1 | |a Mia, Emon |u Department of Pharmacy, Gopalganj Science and Technology University, 8100, Gopalganj, Bangladesh (ROR: https://ror.org/011xjpe74) (GRID: grid.449329.1) (ISNI: 0000 0004 4683 9733) | |
| 700 | 1 | |a Saleh, Na’il |u Department of Chemistry, College of Science, United Arab Emirates University, 15551, POBox, Al Ain, United Arab Emirates (ROR: https://ror.org/01km6p862) (GRID: grid.43519.3a) (ISNI: 0000 0001 2193 6666) | |
| 700 | 1 | |a Almansoori, Mashael A. |u Department of Chemistry, College of Science, United Arab Emirates University, 15551, POBox, Al Ain, United Arab Emirates (ROR: https://ror.org/01km6p862) (GRID: grid.43519.3a) (ISNI: 0000 0001 2193 6666) | |
| 700 | 1 | |a Bappi, Mehedi Hasan |u School of Pharmacy, Jeonbuk National University, 54896, Jeonju, Republic of Korea (ROR: https://ror.org/05q92br09) (GRID: grid.411545.0) (ISNI: 0000 0004 0470 4320) | |
| 700 | 1 | |a Islam, Muhammad Torequl |u Department of Pharmacy, Gopalganj Science and Technology University, 8100, Gopalganj, Bangladesh (ROR: https://ror.org/011xjpe74) (GRID: grid.449329.1) (ISNI: 0000 0004 4683 9733); Bioinformatices and Drug Innovation Laboratory, BioLuster Research Center Ltd, 8100, Gopalganj, Bangladesh (ROR: https://ror.org/02g02v883) | |
| 773 | 0 | |t Scientific Reports (Nature Publisher Group) |g vol. 15, no. 1 (2025), p. 34307-34317 | |
| 786 | 0 | |d ProQuest |t Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3256605227/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3256605227/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3256605227/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |