Topical dobesilate eye drops for ophthalmic primary pterygium

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Publicado en:BMJ Case Reports vol. 2012 (Sep 2025), p. bcr1220115449
Autor principal: Cuevas, Pedro
Otros Autores: Outeiriño, Luis A, Angulo, Javier, Giménez-Gallego, Guillermo
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BMJ Publishing Group LTD
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024 7 |a 10.1136/bcr.12.2011.5449  |2 doi 
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045 2 |b d20250901  |b d20250930 
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100 1 |a Cuevas, Pedro  |u Research, Hospital Ramon y Cajal, Madrid, Spain 
245 1 |a Topical dobesilate eye drops for ophthalmic primary pterygium 
260 |b BMJ Publishing Group LTD  |c Sep 2025 
513 |a Journal Article Case Study 
520 3 |a Selective inhibition of fibroblast growth factor and vascular endothelial growth factor signalling pathways is effective in causing regression of pterygia. Prompt regression of fibrovascular mass and conjunctival angiogenesis was documented 2 weeks after topical administration of dobesilate eye drops twice daily. At 3-month follow-up, no recurrence was seen and no ocular irritation and burning were noted. The authors believe that this is the first known successful use of topical dobesilate in primary pterygium. 
653 |a Diabetes 
653 |a Vascular endothelial growth factor 
653 |a Neutrophils 
653 |a Fibroblasts 
653 |a Stem cells 
653 |a Cornea 
653 |a Angiogenesis 
653 |a Cytokines 
700 1 |a Outeiriño, Luis A  |u Servicio de Oftalmología, Hospital de día Pío XII, Madrid, Madrid, Spain 
700 1 |a Angulo, Javier  |u Research, Hospital Ramon y Cajal, Madrid, Spain 
700 1 |a Giménez-Gallego, Guillermo  |u Qiimica de Proteinas, Centro de Investigaciones Biológicas, Madrid, Spain 
773 0 |t BMJ Case Reports  |g vol. 2012 (Sep 2025), p. bcr1220115449 
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