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Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse

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Izdano u:PLoS One vol. 20, no. 10 (Oct 2025), p. e0334293
Glavni autor: McGill, Sarah H
Daljnji autori: Xin, Qilong, Yadav, Taruna, Zhao, Charlie W, Paszkowski, Patrick, Darby, Fabrizio, Guha, Mrinmoyee, Nguyen, Tramy, Jin, David S, Nir, Yuval, Liu, Jiayang, Lim-Anna Sieu, Blumenfeld, Hal
Izdano:
Public Library of Science
Teme:
Yale University
Somatosensory cortex
Auditory tasks
Electrodes
Brand names
Electrophysiological recording
Animals
Synchronization
Frequencies
Broadband
Cortex (auditory)
Cortex (frontal)
Statistical analysis
Animal models
Thalamus
Order processing
Dental cement
Surgery
Ketamine
Sensory perception
Hearing
Visual cortex
Information processing
Auditory perception
Sensory integration
Environmental
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Sažetak:Studies of human perception have shown early cortical signals for primary information encoding, and later signals for higher order processing. An important late signal is the cortical event-related desynchronization (ERD) in the alpha (8–12 Hz) and beta (12–30 Hz) frequency band, which has been linked to human perceptual awareness. Detailed mechanistic investigation of the ERD would be greatly facilitated by availability of a suitable animal model. We conducted local field potential recordings in the mouse frontal association cortex (FrA), thalamic intralaminar centrolateral nucleus (CL), primary auditory cortex (A1), and primary visual cortex (V1) during two auditory tasks. Fully audible brief 50 ms stimuli with both tasks produced early broadband gamma (30–100 Hz) frequency activity at 0–250ms, followed by a late cortical alpha/beta ERD 250–750 ms after stimulus onset. The ERD was statistically significant in FrA and A1, but not in V1. Interestingly, a significant ERD was also observed in thalamic CL. The magnitude of the ERD at full stimulus intensity, and the slope of the relationship between stimulus intensity versus ERD magnitude, were both largest in FrA, and smaller in CL and A1. Conversely, for early broadband gamma activity the magnitude at full intensity and slopes were largest in A1, smaller in CL and smaller still in FrA. These findings strongly support mice as a promising platform for further investigation of the ERD to better understand the origin and function of this robust yet understudied electrophysiological phenomenon.
ISSN:1932-6203
Digitalni identifikator objekta:10.1371/journal.pone.0334293
Izvor:Health & Medical Collection