Multiple Organ Phenotype of Fatigue

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Publicat a:Biomolecules vol. 15, no. 10 (2025), p. 1476-1494
Autor principal: Liu, Xiaohua
Altres autors: Zhao Zhonghan, Zhang, Yuan, Zou, Jun, Zhang, Lingli
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MDPI AG
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022 |a 2218-273X 
024 7 |a 10.3390/biom15101476  |2 doi 
035 |a 3265837149 
045 2 |b d20250101  |b d20251231 
084 |a 231434  |2 nlm 
100 1 |a Liu, Xiaohua  |u School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; 2511517008@sus.edu.cn (X.L.); 2221516004@sus.edu.cn (Z.Z.); junzou@sus.edu.cn (J.Z.) 
245 1 |a Multiple Organ Phenotype of Fatigue 
260 |b MDPI AG  |c 2025 
513 |a Journal Article 
520 3 |a Fatigue is not only a widespread subjective experience but also a complex physiological and pathological state involving multiple organs and systems. Currently, there is no consensus on the definition and classification of fatigue. Based on its causes, this paper categorizes fatigue into sports fatigue, occupational fatigue, and pathological fatigue. It elaborates on the specific manifestations and underlying mechanisms of fatigue in the motor, nervous, cardiovascular, digestive, urinary, endocrine, and reproductive systems, aiming to uncover the intrinsic connections of fatigue phenotypes across different systems. These findings may provide key targets for gene-assisted therapy of fatigue-related complications, thereby establishing a new theoretical foundation for the clinical management of fatigue and related research. 
653 |a Physiology 
653 |a Exercise 
653 |a Physical fitness 
653 |a Muscle strength 
653 |a Musculoskeletal system 
653 |a Free radicals 
653 |a Adenosine triphosphate 
653 |a Fatigue 
653 |a Phenotypes 
653 |a Bones 
653 |a Muscle contraction 
653 |a Electromyography 
653 |a Metabolism 
653 |a Muscle function 
653 |a Muscle fatigue 
653 |a Metabolites 
700 1 |a Zhao Zhonghan  |u School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; 2511517008@sus.edu.cn (X.L.); 2221516004@sus.edu.cn (Z.Z.); junzou@sus.edu.cn (J.Z.) 
700 1 |a Zhang, Yuan  |u College of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China; 2221111032@sus.edu.cn 
700 1 |a Zou, Jun  |u School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China; 2511517008@sus.edu.cn (X.L.); 2221516004@sus.edu.cn (Z.Z.); junzou@sus.edu.cn (J.Z.) 
700 1 |a Zhang, Lingli  |u College of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China; 2221111032@sus.edu.cn 
773 0 |t Biomolecules  |g vol. 15, no. 10 (2025), p. 1476-1494 
786 0 |d ProQuest  |t Health & Medical Collection 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3265837149/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch 
856 4 0 |3 Full Text + Graphics  |u https://www.proquest.com/docview/3265837149/fulltextwithgraphics/embedded/L8HZQI7Z43R0LA5T?source=fedsrch 
856 4 0 |3 Full Text - PDF  |u https://www.proquest.com/docview/3265837149/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch