Bridging Breeds: Transcriptomic Insights into Immune Traits of Yili, Thoroughbred, and Kazakh Horses

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Detalles Bibliográficos
Publicado en:	Life vol. 15, no. 10 (2025), p. 1496-1516
Autor principal:	Wang, Tongliang
Otros Autores:	Yang, Xixi, Wang Chuankun, Wang, Jianwen, Meng, Jun, Yao Xinkui, Zeng Yaqi, Ren Wanlu
Publicado:	MDPI AG
Materias:	Beijing China Shenzhen China United States > US China Physiology Transcriptomes Erythrocytes Monocytes Software Plasma Animal welfare Disease resistance Immunoregulation Antibodies Adaptability Racehorses Genes Leukocytes (neutrophilic) Quality control Molecular modelling Hogs Breeding methods Anticoagulants NF-κB protein Transcriptomics Antigen processing Blood Immunoglobulins Statistical analysis Signal processing Breeding Parameter identification Hemoglobin Horses Immunoglobulin M Genetic resources Bioengineering Hybrid vigor Immunoglobulin G Athletic performance Signal transduction Variance analysis Immunoglobulin A Environmental
Acceso en línea:	Citation/Abstract Full Text + Graphics Full Text - PDF
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Descripción
Resumen:	Background: Studying the genetic characteristics and molecular mechanisms of immune regulation in horses is of great significance for protecting their genetic resources, improving breeding strategies, and enhancing their disease resistance, thereby ensuring their healthy performance in both sports and production. Aims/objectives: This study investigates the genetic characteristics and molecular mechanisms underlying immune regulation in Yili horses, comparing them with Thoroughbreds and Kazakh horses. Methods: Blood samples from each breed were analyzed for physiological, biochemical, and immune indices alongside transcriptome sequencing to identify differentially expressed genes (DEGs). Results: The results revealed significant differences in neutrophil counts, monocytes, red blood cell parameters, glucose levels, and immunoglobulins (IgA, IgG, IgM) among breeds. Yili horses exhibited intermediate values for most parameters, aligning more closely with Thoroughbreds. Transcriptomic analysis identified 3574 DEGs, enriched in immune-related pathways such as platelet activation, antigen processing, and cytokine signaling. Key genes, including TNFRSF14, IFIT3, and IL21R, correlated with immune traits, highlighting hybrid vigor in Yili horses. Functional enrichment underscored pathways like IL-17 signaling and NF-κB regulation, linking genetic differences to immune adaptability. Conclusions: These findings provide molecular insights into breed-specific immune traits, supporting strategies to enhance disease resilience in Yili horses while preserving their athletic performance. This study underscores the importance of integrating transcriptomic and phenotypic data for informed breeding practices in equine conservation and improvement.
ISSN:	2075-1729
DOI:	10.3390/life15101496
Fuente:	Biological Science Database