Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study
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| Publicat a: | Psychological Medicine vol. 55 (Oct 2025) |
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| Autor principal: | |
| Altres autors: | , , , , , , , |
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Cambridge University Press
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| Accés en línia: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 022 | |a 0033-2917 | ||
| 022 | |a 1469-8978 | ||
| 024 | 7 | |a 10.1017/S0033291725102304 |2 doi | |
| 035 | |a 3266717859 | ||
| 045 | 2 | |b d20251001 |b d20251031 | |
| 084 | |a 66193 |2 nlm | ||
| 100 | 1 | |a Hyat, Mahnoor |u Department of Psychology, https://ror.org/00cvxb145 University of Washington, Seattle, WA, USA | |
| 245 | 1 | |a Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study | |
| 260 | |b Cambridge University Press |c Oct 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Background Subtle behavioral and cognitive symptoms precede schizophrenia (SCZ) and appear in individuals with elevated risk based on polygenic risk scores (SCZ-PRS) and family history of psychosis (SCZ-FH). However, most SCZ-PRS studies focus on European ancestry youth, limiting generalizability. Furthermore, it remains unclear whether SCZ-FH reflects common-variant polygenic risk or broader SCZ liability. Methods Using baseline data from the Adolescent Brain Cognitive Development (ABCD) study, we investigated associations of SCZ-FH and SCZ-PRS with cognitive, behavioral, and emotional measures from NIH-Toolbox, Child Behavior Checklist (CBCL), and Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) for 9,636 children (mean age = 9.92 yrs, 47.4% female), specifically, 5,636 European, 2,093 African, and 1,477 Admixed American ancestry individuals. Results SCZ-FH was associated with SCZ-PRS (b = 0.05, FDR-p = 0.02) and subthreshold psychotic symptoms (b = 0.46, FDR-p = 0.01) in European youth, higher CBCL scores (b range = 0.36–0.6, FDR-p < 0.001), and higher odds of multiple internalizing and externalizing disorders (OR = 1.10–1.22, FDR-p < 0.001) across ancestries. SCZ-PRS was associated with lower cognition across ancestries (b = −0.43, FDR-p = 0.02), higher CBCL total problems, anxious/depressed, rule-breaking and aggressive behaviors in European youth (b range = 0.16–0.33, FDR-p < 0.04), and depressive disorders in Admixed American youth (OR = 1.37, FDR-p = 0.02). Results remained consistent when SCZ-PRS and SCZ-FH were jointly modeled. Some SCZ-FH associations weakened when income-to-needs was accounted for, suggesting that SCZ-FH may capture both genetic and environmental influences. Conclusions SCZ-FH showed associations with broad psychopathology, while SCZ-PRS was associated with cognition and specific symptoms in European youth. Findings highlight their complementary role in SCZ risk assessment and the need to improve PRS utility across ancestries. | |
| 651 | 4 | |a United States--US | |
| 653 | |a Genealogy | ||
| 653 | |a Accuracy | ||
| 653 | |a Cognition | ||
| 653 | |a Psychopathology | ||
| 653 | |a Schizophrenia | ||
| 653 | |a Mental disorders | ||
| 653 | |a Risk assessment | ||
| 653 | |a Families & family life | ||
| 653 | |a Affective disorders | ||
| 653 | |a Standard scores | ||
| 653 | |a Environmental aspects | ||
| 653 | |a Externalizing problems | ||
| 653 | |a Child Behavior Checklist | ||
| 653 | |a Aggressive behavior | ||
| 653 | |a Child development | ||
| 653 | |a Psychosis | ||
| 653 | |a Mental depression | ||
| 653 | |a Associations | ||
| 653 | |a Cognitive development | ||
| 653 | |a Internalization | ||
| 653 | |a Psychotic symptoms | ||
| 653 | |a Cognitive-behavioral factors | ||
| 653 | |a Intellectual development | ||
| 653 | |a Emotional behavior | ||
| 653 | |a Generalizability | ||
| 653 | |a Children & youth | ||
| 653 | |a Behavior | ||
| 653 | |a Emotional disorders | ||
| 653 | |a Childhood | ||
| 653 | |a Youth | ||
| 653 | |a Brain | ||
| 653 | |a Behavior problems | ||
| 653 | |a Children | ||
| 653 | |a Liability | ||
| 653 | |a Genetics | ||
| 653 | |a Adolescent development | ||
| 653 | |a Disorders | ||
| 653 | |a Symptoms | ||
| 700 | 1 | |a Zhu, Jinhan |u Department of Psychology, https://ror.org/00cvxb145 University of Washington, Seattle, WA, USA | |
| 700 | 1 | |a Boltz, Toni A. |u Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA | |
| 700 | 1 | |a Conomos, Matthew P. |u Department of Biostatistics, https://ror.org/00cvxb145 University of Washington, Seattle, WA, USA | |
| 700 | 1 | |a Hughes, Dylan E. |u Department of Psychology, University of California, Los Angeles, CA, USA | |
| 700 | 1 | |a Fohner, Alison E. |u Institute for Public Health Genetics, https://ror.org/00cvxb145 University of Washington, WA, USA | |
| 700 | 1 | |a Foster, Katherine T. |u Department of Global Health, https://ror.org/00cvxb145 University of Washington, WA, USA | |
| 700 | 1 | |a Bigdeli, Tim B. |u Department of Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY, USA | |
| 700 | 1 | |a Forsyth, Jennifer K. |u Institute for Public Health Genetics, https://ror.org/00cvxb145 University of Washington, WA, USA | |
| 773 | 0 | |t Psychological Medicine |g vol. 55 (Oct 2025) | |
| 786 | 0 | |d ProQuest |t Sociology Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3266717859/abstract/embedded/Q8Z64E4HU3OH5N8U?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3266717859/fulltextwithgraphics/embedded/Q8Z64E4HU3OH5N8U?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3266717859/fulltextPDF/embedded/Q8Z64E4HU3OH5N8U?source=fedsrch |