Breast Cancer Therapy: Harnessing Biocompatible Zinc-manganese Nano-platform for Dual-targeted Photodynamic Therapy
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| Опубликовано в:: | Journal of Inorganic and Organometallic Polymers and Materials vol. 34, no. 10 (Oct 2024), p. 4950 |
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| Главный автор: | |
| Другие авторы: | , , , , |
| Опубликовано: |
Springer Nature B.V.
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| Предметы: | |
| Online-ссылка: | Citation/Abstract Full Text Full Text - PDF |
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Нет меток, Требуется 1-ая метка записи!
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| 035 | |a 3267008940 | ||
| 045 | 2 | |b d20241001 |b d20241031 | |
| 100 | 1 | |a Zamani-Roudbaraki, Mostafa |u University of Guilan, Department of Organic Chemistry, Faculty of Chemistry, Rasht, Iran (GRID:grid.411872.9) (ISNI:0000 0001 2087 2250) | |
| 245 | 1 | |a Breast Cancer Therapy: Harnessing Biocompatible Zinc-manganese Nano-platform for Dual-targeted Photodynamic Therapy | |
| 260 | |b Springer Nature B.V. |c Oct 2024 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a In this project, five different nanoparticles based on different ratios of iron, zinc, and manganese were synthesized to form Znx Mn1-X Fe2O4. Then, one of them was selected and polyethylene glycol was conjugated to its surface using tartaric acid to improve its biocompatibility. Also, to improve the target ability of the prepared polyethylene glycol conjugated Znx Mn1-X Fe2O4 as a nano-platform, folic acid was used as a targeting agent. The nano-platform was characterized using different techniques such as X-ray diffractometey, vibrating-sample magnetometer, ultraviolet–visible spectroscopy, field emission-scanning electron microscopy, Fourier-transform infrared spectroscopy and thermogravimetric analysis. In vivo and in vitro tests including hemolysis, blood aggregation and lethal dose showed that Zn0.5Mn0.5 Fe2O4 were the most suitable photosensitizers among all. Also, in vivo and in vitro biocompatibility analysis revealed that incorporation of polyethylene glycol can significantly improve the biocompatibility of the nano-platforms. The cytotoxicity results revealed that cell viability of cancerous cells was lower when the nano-platform was coated with folic acid and poly ethylene glycol under irradiation of visible light while whiteout shining the light, the cell viability was almost 100% for polyethylene coated nano-platform. These results can prove the great potential of folic acid to improve the photodynamic therapy performance of Zn0.5Mn0.5 Fe2O4. | |
| 653 | |a Metals | ||
| 653 | |a In vitro methods and tests | ||
| 653 | |a Ferrites | ||
| 653 | |a Chloride | ||
| 653 | |a Zinc | ||
| 653 | |a Spectrum analysis | ||
| 653 | |a Thermogravimetric analysis | ||
| 653 | |a Cancer therapies | ||
| 653 | |a Infrared analysis | ||
| 653 | |a Field emission spectroscopy | ||
| 653 | |a Biocompatibility | ||
| 653 | |a Tartaric acid | ||
| 653 | |a Photodynamic therapy | ||
| 653 | |a Folic acid | ||
| 653 | |a In vivo methods and tests | ||
| 653 | |a Manganese | ||
| 653 | |a Polyethylene glycol | ||
| 653 | |a Fourier transforms | ||
| 700 | 1 | |a Aghajanzadeh-Kiyaseh, Mozhgan |u University of Guilan, Department of Organic Chemistry, Faculty of Chemistry, Rasht, Iran (GRID:grid.411872.9) (ISNI:0000 0001 2087 2250) | |
| 700 | 1 | |a Shahangian, S. Shirin |u University of Guilan, Department of Biology, Faculty of Sciences, Rasht, Iran (GRID:grid.411872.9) (ISNI:0000 0001 2087 2250) | |
| 700 | 1 | |a Jashnani, Setare |u University of Guilan, Department of Organic Chemistry, Faculty of Chemistry, Rasht, Iran (GRID:grid.411872.9) (ISNI:0000 0001 2087 2250) | |
| 700 | 1 | |a Khoramabadi, Hossein |u University of Guilan, Department of Organic Chemistry, Faculty of Chemistry, Rasht, Iran (GRID:grid.411872.9) (ISNI:0000 0001 2087 2250) | |
| 700 | 1 | |a Shirini, Farhad |u University of Guilan, Department of Organic Chemistry, Faculty of Chemistry, Rasht, Iran (GRID:grid.411872.9) (ISNI:0000 0001 2087 2250) | |
| 773 | 0 | |t Journal of Inorganic and Organometallic Polymers and Materials |g vol. 34, no. 10 (Oct 2024), p. 4950 | |
| 786 | 0 | |d ProQuest |t Materials Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3267008940/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
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