Monitoring strategies after the incorporation of vaccines into national immunization programs: a systematic review

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Publicat a:Vaccine vol. 66 (Nov 14, 2025)
Autor principal: de Melo Araújo, Ana Catarina
Altres autors: Frugoli, Alice Gomes, de Sena Gonçalves, Jéssica Emanuela, Pércio, Jadher, Da Silva, Thiago Petra, da Fonseca Victer, Thayssa Neiva, Matozinhos, Fernanda Penido, Fernandes, Éder Gatti
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Elsevier Limited
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022 |a 0264-410X 
022 |a 1873-2518 
024 7 |a 10.1016/j.vaccine.2025.127850  |2 doi 
035 |a 3267317593 
045 0 |b d20251114 
084 |a 109921  |2 nlm 
100 1 |a de Melo Araújo, Ana Catarina 
245 1 |a Monitoring strategies after the incorporation of vaccines into national immunization programs: a systematic review 
260 |b Elsevier Limited  |c Nov 14, 2025 
513 |a Literature Review 
520 3 |a Introduction and objective The 2030 Immunization Agenda envisions a global landscape where everyone can equally access the benefits of both new and existing vaccines by expanding equitable coverage. Post-introduction evaluation strategies are essential to ensure efficient and rational use of resources invested in immunization programs. However, a notable gap remains in the literature on how these strategies are applied in low- and middle-income countries. This study identify the main strategies used worldwide to monitor vaccines after their incorporation into immunization programs. Methods This systematic literature review was conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions and reported following PRISMA guidelines. Studies were retrieved from PubMed (MEDLINE), Web of Science, Core Collection, SCOPUS, and EMBASE (Elsevier) databases. The review included studies on vaccine monitoring after incorporation into immunization programs, with no date restrictions. Excluded were narrative and systematic reviews, meta-analyses, letters, book chapters, posters, COVID-19 vaccine studies, non-human vaccination research, and studies assessing general impact without post-introduction monitoring. Results The search identified 4812 citations, with 1477 duplicates removed. After screening 3335 titles and abstracts, nine studies met the inclusion criteria. While the concept of post-introduction monitoring strategies remains poorly defined, the studies revealed that such monitoring can be performed through evaluation of surveillance systems, economic assessments, and adapted analytical tools. Sentinel surveillance, involving healthcare workers and services, was the most frequently reported strategy, followed by synthetic control methods, pre- and post-introduction comparisons, and use of a World Health Organization tool. Conclusions Despite the absence of a standardized framework for post-introduction vaccine monitoring, existing studies demonstrate that evaluations can address effectiveness, safety, coverage, and cost. Beyond epidemiological significance, the incorporation of vaccines into immunization programs provides an opportunity to strengthen policies, promote workforce development, and foster social mobilization in support of vaccination. 
651 4 |a United Kingdom--UK 
653 |a Infectious diseases 
653 |a Quality of life 
653 |a Population 
653 |a COVID-19 vaccines 
653 |a Literature reviews 
653 |a Vaccines 
653 |a Epidemiology 
653 |a Medical personnel 
653 |a Mortality 
653 |a Public health 
653 |a Developing countries--LDCs 
653 |a Monitoring 
653 |a Control methods 
653 |a Immunization 
653 |a Surveillance systems 
653 |a Systematic review 
653 |a Social 
700 1 |a Frugoli, Alice Gomes 
700 1 |a de Sena Gonçalves, Jéssica Emanuela 
700 1 |a Pércio, Jadher 
700 1 |a Da Silva, Thiago Petra 
700 1 |a da Fonseca Victer, Thayssa Neiva 
700 1 |a Matozinhos, Fernanda Penido 
700 1 |a Fernandes, Éder Gatti 
773 0 |t Vaccine  |g vol. 66 (Nov 14, 2025) 
786 0 |d ProQuest  |t Healthcare Administration Database 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3267317593/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text  |u https://www.proquest.com/docview/3267317593/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text - PDF  |u https://www.proquest.com/docview/3267317593/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch