Evaluation of the Allergy Fact Checker, a clinical decision support system for non-invasive beta-lactam delabeling: a mixed-methods study
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| Yayımlandı: | NPJ Digital Medicine vol. 8, no. 1 (Dec 2025), p. 662-669 |
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| Diğer Yazarlar: | , , , , , , |
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Nature Publishing Group
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| Online Erişim: | Citation/Abstract Full Text Full Text - PDF |
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| 024 | 7 | |a 10.1038/s41746-025-02030-1 |2 doi | |
| 035 | |a 3272809324 | ||
| 045 | 2 | |b d20251201 |b d20251231 | |
| 100 | 1 | |a Van De Sijpe, Greet |u KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884); Pharmacy Department, UZ Leuven, Leuven, Belgium (ROR: https://ror.org/0424bsv16) (GRID: grid.410569.f) (ISNI: 0000 0004 0626 3338) | |
| 245 | 1 | |a Evaluation of the Allergy Fact Checker, a clinical decision support system for non-invasive beta-lactam delabeling: a mixed-methods study | |
| 260 | |b Nature Publishing Group |c Dec 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Penicillin allergy delabeling strategies are time- and resource-consuming. In this mixed-methods study, we evaluated the ‘Allergy Fact Checker’, a novel clinical decision support system designed to identify patients with uneventful re-exposure to penicillins, enabling delabeling without additional testing. The intervention involved implementation of the tool, pharmacist-led review of alerts, and physician contact. An interrupted time series analysis assessed delabeling outcomes, and physicians were interviewed to explore implementation barriers. The Allergy Fact Checker identified 8.9% (164/1850) of patients with a penicillin allergy label. The delabeling rate increased from 12% to 60% (OR 6.8 (95% CI 1.3–35, P = 0.02)). Addressing one alert took 5 min ( ± 3 min). Reported barriers included workload and limited knowledge of the allergy label removal process. By streamlining the identification process, the Allergy Fact Checker offers a low-resource, scalable solution that significantly improves delabeling and integrates easily into existing clinical workflows. | |
| 653 | |a Patients | ||
| 653 | |a Length of stay | ||
| 653 | |a Clinical medicine | ||
| 653 | |a Hypotheses | ||
| 653 | |a Anaphylaxis | ||
| 653 | |a Antibiotics | ||
| 653 | |a Staphylococcus infections | ||
| 653 | |a Histamine | ||
| 653 | |a Hospitals | ||
| 653 | |a Allergies | ||
| 653 | |a Clinical decision making | ||
| 653 | |a Information systems | ||
| 653 | |a Decision support systems | ||
| 653 | |a Registration | ||
| 653 | |a Algorithms | ||
| 653 | |a Computerized physician order entry | ||
| 653 | |a Time series | ||
| 653 | |a Penicillin | ||
| 653 | |a Hospitalization | ||
| 700 | 1 | |a Gilissen, Liesbeth |u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884) | |
| 700 | 1 | |a Wets, Dries |u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884); Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium (ROR: https://ror.org/0424bsv16) (GRID: grid.410569.f) (ISNI: 0000 0004 0626 3338) | |
| 700 | 1 | |a Breynaert, Christine |u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884); Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium (ROR: https://ror.org/0424bsv16) (GRID: grid.410569.f) (ISNI: 0000 0004 0626 3338) | |
| 700 | 1 | |a Ieven, Toon |u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884); Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium (ROR: https://ror.org/0424bsv16) (GRID: grid.410569.f) (ISNI: 0000 0004 0626 3338) | |
| 700 | 1 | |a De Munter, Paul |u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884); Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium (ROR: https://ror.org/0424bsv16) (GRID: grid.410569.f) (ISNI: 0000 0004 0626 3338) | |
| 700 | 1 | |a Schrijvers, Rik |u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884); Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium (ROR: https://ror.org/0424bsv16) (GRID: grid.410569.f) (ISNI: 0000 0004 0626 3338) | |
| 700 | 1 | |a Spriet, Isabel |u KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, Leuven, Belgium (ROR: https://ror.org/05f950310) (GRID: grid.5596.f) (ISNI: 0000 0001 0668 7884); Pharmacy Department, UZ Leuven, Leuven, Belgium (ROR: https://ror.org/0424bsv16) (GRID: grid.410569.f) (ISNI: 0000 0004 0626 3338) | |
| 773 | 0 | |t NPJ Digital Medicine |g vol. 8, no. 1 (Dec 2025), p. 662-669 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
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