Tube2FEM: a general-purpose highly automated pipeline for flow-related processes in (embedded) tubular objects

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Publicado en:Royal Society Open Science vol. 12, no. 8 (2025), p. 1-23
Autor principal: Sleiman, Hani Cheikh
Otros Autores: Moerman, Kevin M, De Oliveira, Diana C, Jacob, Joseph, Mogulkoc, Nesrin, Davidson, Brian R, Walker-Samuel, Simon, Shipleya, Rebecca J
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The Royal Society Publishing
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022 |a 2054-5703 
024 7 |a 10.1098/rsos.242025  |2 doi 
035 |a 3273072423 
045 2 |b d20250101  |b d20251231 
100 1 |a Sleiman, Hani Cheikh  |u Department of Mechanical Engineering 
245 1 |a Tube2FEM: a general-purpose highly automated pipeline for flow-related processes in (embedded) tubular objects 
260 |b The Royal Society Publishing  |c 2025 
513 |a Journal Article 
520 3 |a This paper presents an open-source pipeline for simulating flow and flow-related processes in (embedded) tubular structures. Addressing a gap in computational fluid dynamics (CFD) and simulation sciences, it facilitates the transition from raw three-dimensional imaging, graph networks or computer aided design (CAD) models of tubular objects to refined, simulation-ready meshes. This transition, traditionally labourintensive, is streamlined through a series of innovative steps that include surface mesh processing, centre-line construction, anisotropic mesh generation and volumetric meshing, leading to finite element method (FEM) simulations. The pipeline leverages a range of open-source software and libraries, notably GIBBON, FEniCS and Paraview, to provide flexibility and broad applicability across different simulation scenarios, ranging from biomedical to industrial applications. We demonstrate the versatility of our approach through five applications, including the mesh generation for soil-root systems, lung airways, microcirculation networks and portal vein networks, each originating from a different data source. Moreover, for several of these cases, we incorporate CFD simulations and strategies for 3D-1D coupling between the embedding domain and the embedded structures. Finally, we outline some future perspectives aimed at enhancing accuracy, reducing computational time and incorporating advanced modelling and boundary condition strategies to further refine the framework's capabilities. 
653 |a Finite element method 
653 |a Tomography 
653 |a Software packages 
653 |a Hydrodynamics 
653 |a Datasets 
653 |a Boundary conditions 
653 |a Fluid dynamics 
653 |a Mathematical models 
653 |a Open source software 
653 |a Computer applications 
653 |a Embedded structures 
653 |a Automation 
653 |a Visualization 
653 |a Linear algebra 
653 |a Simulation 
653 |a Flow simulation 
653 |a Partial differential equations 
653 |a Public domain 
653 |a Industrial applications 
653 |a Computer aided design--CAD 
653 |a Portal vein 
653 |a Three dimensional imaging 
653 |a Networks 
653 |a Computational fluid dynamics 
653 |a Embedding 
653 |a Computer graphics 
653 |a Computing time 
653 |a Mesh generation 
653 |a Environmental 
700 1 |a Moerman, Kevin M  |u Department of Mechanical Engineering, University of Galway, Galway, Ireland 
700 1 |a De Oliveira, Diana C  |u Department of Mechanical Engineering 
700 1 |a Jacob, Joseph  |u Satsuma Lab, Hawkes Institute, University College London, London, UK 
700 1 |a Mogulkoc, Nesrin  |u Department of Respiratory Medicine, Ege University Hospital, Izmir, Turkey 
700 1 |a Davidson, Brian R 
700 1 |a Walker-Samuel, Simon 
700 1 |a Shipleya, Rebecca J 
773 0 |t Royal Society Open Science  |g vol. 12, no. 8 (2025), p. 1-23 
786 0 |d ProQuest  |t Science Database 
856 4 1 |3 Citation/Abstract  |u https://www.proquest.com/docview/3273072423/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text  |u https://www.proquest.com/docview/3273072423/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch 
856 4 0 |3 Full Text - PDF  |u https://www.proquest.com/docview/3273072423/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch