Combined Effects of Diazoxide and Moderate-Intensity Exercise on the Restoration of Redox Balance Post-Fatigue in Fast- and Slow-Twitch Skeletal Muscles of Hypertensive Rats
Guardat en:
| Publicat a: | Biology vol. 14, no. 11 (2025), p. 1553-1570 |
|---|---|
| Autor principal: | |
| Altres autors: | , , , , , , , , , |
| Publicat: |
MDPI AG
|
| Matèries: | |
| Accés en línia: | Citation/Abstract Full Text + Graphics Full Text - PDF |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|
MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3275502884 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2079-7737 | ||
| 024 | 7 | |a 10.3390/biology14111553 |2 doi | |
| 035 | |a 3275502884 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 231432 |2 nlm | ||
| 100 | 1 | |a Bravo-Sánchez Estefanía |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 245 | 1 | |a Combined Effects of Diazoxide and Moderate-Intensity Exercise on the Restoration of Redox Balance Post-Fatigue in Fast- and Slow-Twitch Skeletal Muscles of Hypertensive Rats | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Muscle fatigue is linked to redox imbalance and worsens under hypertension due to oxidative stress. This study tested whether diazoxide and moderate exercise could protect skeletal muscles in hypertensive rats after a fatigue protocol. Hypertension increased oxidants and reduced antioxidant defenses. Both interventions, when used alone or in combination, improved antioxidant activity and reduced oxidant levels. The combined treatment showed the most potent effect, with muscle-specific differences: fast-twitch fibers responded better to exercise, while slow-twitch fibers benefited more from the combined approach. These findings demonstrate how this strategy could inform new treatments for hypertension-induced muscle dysfunction. Muscle fatigue, defined as a decline in force generation, is closely linked to redox imbalance—a condition exacerbated by oxidative stress in hypertension. This study investigated the effects of diazoxide administration and moderate-intensity exercise on skeletal muscle redox status following a fatigue protocol in rats with hypertension. Animals were assigned to eight groups: control (CTRL), diazoxide (DZX), exercise (EX), exercise + diazoxide (EX+DZX), hypertension (HTN), hypertension + diazoxide (HTN+DZX), hypertension + exercise (HTN+EX), and hypertension + exercise + diazoxide (HTN+ EX+DZX). Hypertension was induced by a high-salt diet. Diazoxide was administered daily for 14 days, and exercise consisted of moderate treadmill running for 8 weeks. Muscle fatigue was evoked in the extensor digitorum longus (EDL) and soleus by repetitive electrical stimulation. Post-fatigue analyses included oxidant levels, catalase activity, and glutathione status. Hypertension increased oxidants and reduced antioxidant defenses in both muscle types. Exercise and diazoxide, alone or in combination, improved redox balance, with the combined treatment providing the most robust protection and exhibiting fiber-specific adaptations. These findings suggest that diazoxide combined with moderate exercise represents a promising therapeutic approach to counteract oxidative stress-related skeletal muscle dysfunction in hypertension. | |
| 651 | 4 | |a United States--US | |
| 653 | |a Exercise | ||
| 653 | |a Diabetes | ||
| 653 | |a Physical fitness | ||
| 653 | |a Glutathione | ||
| 653 | |a Muscle strength | ||
| 653 | |a Neurosciences | ||
| 653 | |a Antioxidants | ||
| 653 | |a Metabolism | ||
| 653 | |a Fitness equipment | ||
| 653 | |a Muscle fatigue | ||
| 653 | |a Oxidants | ||
| 653 | |a Rodents | ||
| 653 | |a Electrical stimuli | ||
| 653 | |a Laboratory animals | ||
| 653 | |a Oxidative stress | ||
| 653 | |a Homeostasis | ||
| 653 | |a Materials fatigue | ||
| 653 | |a Hypertension | ||
| 653 | |a Musculoskeletal system | ||
| 653 | |a Blood pressure | ||
| 653 | |a Skeletal muscle | ||
| 653 | |a Obesity | ||
| 653 | |a Muscle function | ||
| 700 | 1 | |a Nolasco-Ruiz, César J |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 700 | 1 | |a Sánchez-Duarte, Sarai |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 700 | 1 | |a Gómez-Barroso, Mariana |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 700 | 1 | |a Vargas-Vargas, Manuel Alejandro |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 700 | 1 | |a Cortés-Rojo, Christian |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 700 | 1 | |a Manzo-Ávalos Salvador |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 700 | 1 | |a Sánchez-Duarte, Elizabeth |u Departamento de Ciencias Aplicadas al Trabajo, Universidad Guanajuato Campus León, León 37128, Guanajuato, Mexico; elizabeth.sanchez@ugto.mx | |
| 700 | 1 | |a Rodríguez-Orozco, Alain Raimundo |u Facultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chávez”, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58000, Michoacán, Mexico | |
| 700 | 1 | |a Saavedra-Molina, Alfredo |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 700 | 1 | |a Montoya-Pérez Rocío |u Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana San Nicolás de Hidalgo, Morelia 58040, Michoacán, Mexico; 1541910b@umich.mx (E.B.-S.); 1209814b@umich.mx (C.J.N.-R.); 1315649c@umich.mx (S.S.-D.); mariana.gomez@ucq.edu.mx (M.G.-B.); manuel.alejandro.vargas@umich.mx (M.A.V.-V.); christian.cortes@umich.mx (C.C.-R.); smanzo@umich.mx (S.M.-Á.); francisco.saavedra@umich.mx (A.S.-M.) | |
| 773 | 0 | |t Biology |g vol. 14, no. 11 (2025), p. 1553-1570 | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3275502884/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3275502884/fulltextwithgraphics/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3275502884/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |