Genetic Determinants of Obesity and Cardiometabolic Outcomes: Insights From Mendelian Randomization and Surgical Response Studies
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| Publicat a: | ProQuest Dissertations and Theses (2025) |
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ProQuest Dissertations & Theses
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| Accés en línia: | Citation/Abstract Full Text - PDF |
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| 100 | 1 | |a Wu, Yuchao Taylor | |
| 245 | 1 | |a Genetic Determinants of Obesity and Cardiometabolic Outcomes: Insights From Mendelian Randomization and Surgical Response Studies | |
| 260 | |b ProQuest Dissertations & Theses |c 2025 | ||
| 513 | |a Dissertation/Thesis | ||
| 520 | 3 | |a This thesis examines genetic influences on obesity, cardiometabolic traits, and bariatric surgery outcomes. The first study used a sex-stratified Mendelian randomization to investigate the causal effect of corrected insulin response (CIR) on cardiometabolic diseases. Our data suggests that higher CIR may protect against type 2 diabetes and dyslipidemia, without exerting adverse effects on coronary artery disease in both sexes. In females, CIR may increase BMI. But it may also increase leg fat, which is thought to be metabolically favorable. The second study assessed the association between the fraction of the genome in runs of homozygosity (FROH), in relation to both BMI and percentage weight loss (PWL) one-year after bariatric surgery. FROH was not significantly associated with pre-operative BMI. However, the cumulative ROH length in an individual is positively associated with higher BMI. No significant association was found between FROH and one-year PWL. This awaits confirmation in larger and well-powered studies. | |
| 653 | |a Genetics | ||
| 653 | |a Epidemiology | ||
| 653 | |a Nutrition | ||
| 773 | 0 | |t ProQuest Dissertations and Theses |g (2025) | |
| 786 | 0 | |d ProQuest |t ProQuest Dissertations & Theses Global | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3276301550/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3276301550/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |