Central nervous system and immune cells interactions in cancer: unveiling new therapeutic avenues
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| Publicat a: | Frontiers in Immunology vol. 16 (Feb 2025), p. 1528363-1528383 |
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| Autor principal: | |
| Altres autors: | , , |
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Frontiers Media SA
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| Accés en línia: | Citation/Abstract Full Text Full Text - PDF |
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| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3278222019 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1664-3224 | ||
| 024 | 7 | |a 10.3389/fimmu.2025.1528363 |2 doi | |
| 035 | |a 3278222019 | ||
| 045 | 2 | |b d20250201 |b d20250228 | |
| 100 | 1 | |a Wen, Junkai |u Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China | |
| 245 | 1 | |a Central nervous system and immune cells interactions in cancer: unveiling new therapeutic avenues | |
| 260 | |b Frontiers Media SA |c Feb 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Cancer remains a leading cause of mortality worldwide. Despite significant advancements in cancer research, our understanding of its complex developmental pathways remains inadequate. Recent research has clarified the intricate relationship between the central nervous system (CNS) and cancer, particularly how the CNS influences tumor growth and metastasis via regulating immune cell activity. The interactions between the central nervous system and immune cells regulate the tumor microenvironment via various signaling pathways, cytokines, neuropeptides, and neurotransmitters, while also incorporating processes that alter the tumor immunological landscape. Furthermore, therapeutic strategies targeting neuro-immune cell interactions, such as immune checkpoint inhibitors, alongside advanced technologies like brain-computer interfaces and nanodelivery systems, exhibit promise in improving treatment efficacy. This complex bidirectional regulatory network significantly affects tumor development, metastasis, patient immune status, and therapy responses. Therefore, understanding the mechanisms regulating CNS-immune cell interactions is crucial for developing innovative therapeutic strategies. This work consolidates advancements in CNS-immune cell interactions, evaluates their potential in cancer treatment strategies, and provides innovative insights for future research and therapeutic approaches. | |
| 653 | |a Immune status | ||
| 653 | |a Metastasis | ||
| 653 | |a Neuropeptides | ||
| 653 | |a Immune checkpoint inhibitors | ||
| 653 | |a Brain research | ||
| 653 | |a Immunology | ||
| 653 | |a Cytokines | ||
| 653 | |a Tumors | ||
| 653 | |a Cell interactions | ||
| 653 | |a Central nervous system | ||
| 653 | |a Metastases | ||
| 653 | |a Neurotransmitters | ||
| 653 | |a Influence | ||
| 653 | |a Clinical outcomes | ||
| 653 | |a Medical innovations | ||
| 653 | |a Cancer research | ||
| 653 | |a Neuroblastoma | ||
| 653 | |a Blood-brain barrier | ||
| 653 | |a Medical prognosis | ||
| 653 | |a Cell adhesion & migration | ||
| 653 | |a Immune system | ||
| 653 | |a Medical research | ||
| 653 | |a Immune response | ||
| 653 | |a Lymphocytes | ||
| 653 | |a Tumor microenvironment | ||
| 653 | |a Nervous system | ||
| 653 | |a Cancer therapies | ||
| 700 | 1 | |a Li, Yue |u Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China | |
| 700 | 1 | |a Deng, Wanli |u Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China | |
| 700 | 1 | |a Li, Zhi |u Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, Department of General Surgery, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, China | |
| 773 | 0 | |t Frontiers in Immunology |g vol. 16 (Feb 2025), p. 1528363-1528383 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3278222019/abstract/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3278222019/fulltext/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3278222019/fulltextPDF/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |