Unraveling the immune system’s role in peripheral nerve regeneration: a pathway to enhanced healing
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| Publicado en: | Frontiers in Immunology vol. 16 (Feb 2025), p. 1540199-1540211 |
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| Autor principal: | |
| Otros Autores: | , , , , , , , , , , |
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Frontiers Media SA
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| Acceso en línea: | Citation/Abstract Full Text Full Text - PDF |
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| 022 | |a 1664-3224 | ||
| 024 | 7 | |a 10.3389/fimmu.2025.1540199 |2 doi | |
| 035 | |a 3278264270 | ||
| 045 | 2 | |b d20250201 |b d20250228 | |
| 100 | 1 | |a Zhang, Xu |u Xu Zhang [AFFILIATION="Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration | |
| 245 | 1 | |a Unraveling the immune system’s role in peripheral nerve regeneration: a pathway to enhanced healing | |
| 260 | |b Frontiers Media SA |c Feb 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Peripheral nerve injury (PNI) represents a common challenge in clinical practice. In contrast to the central nervous system (CNS), the peripheral nervous system (PNS) in mature mammals possesses a limited regenerative capacity. Upon the occurrence of PNI, peripheral nerve regeneration (PNR) is initiated, facilitated by the activation of the immune microenvironment and the intrinsic growth potential of neurons. This regenerative process encompasses several key stages, including distal axon degeneration, myelin breakdown, clearance of myelin debris, inflammatory responses from non-neuronal cells, and subsequent axonal regeneration. The immune response, recognized for its role in clearing myelin debris and modulating the local inflammatory milieu, is crucial for initiating axonal regeneration at the proximal stump of nerves. Nevertheless, the precise mechanisms by which the immune response influences PNI and the strategies to harness this process to augment regeneration remain elusive. This article provides a comprehensive overview of the diverse roles and mechanisms of the immune system in PNR and presents insights into potential therapeutic strategies. Furthermore, the article examines immune-associated signaling pathways and their impact on PNR, underscoring the significance of immune modulation in enhancing patient outcomes with PNI. Ultimately, it encapsulates and forecasts the theoretical and practical directions of this field. | |
| 653 | |a Growth factors | ||
| 653 | |a Myelin | ||
| 653 | |a Neurons | ||
| 653 | |a Immune clearance | ||
| 653 | |a Immunity (Disease) | ||
| 653 | |a Peripheral nerves | ||
| 653 | |a Immune system | ||
| 653 | |a Cytokines | ||
| 653 | |a Immune response | ||
| 653 | |a Injuries | ||
| 653 | |a Regeneration | ||
| 653 | |a Extracellular matrix | ||
| 653 | |a Immunomodulation | ||
| 653 | |a Tumor necrosis factor-TNF | ||
| 653 | |a Nervous system | ||
| 653 | |a Recruitment | ||
| 653 | |a Microenvironments | ||
| 653 | |a Central nervous system | ||
| 653 | |a Brain-derived neurotrophic factor | ||
| 653 | |a Genotype & phenotype | ||
| 653 | |a Wound healing | ||
| 653 | |a Inflammation | ||
| 700 | 1 | |a Department of Pharmacy, Affiliated Hospital of Nantong University | |
| 700 | 1 | |a School of Life Science, Nantong Laboratory of Development and Diseases | |
| 700 | 1 | |a Medical School, Nantong University, Nantong, China, Clinical Medical Research Center, Department of Neurosurgery, Affiliated Wuxi Clinical College of Nantong University, Wuxi No.2 Peolpe’s Hospital, Jiangnan University Medical Center, Wuxi, China"] | |
| 700 | 1 | |a Zhang, Yanxian |u Yanxian Zhang [AFFILIATION="Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration | |
| 700 | 1 | |a Medical School, Nantong University, Nantong, China"] | |
| 700 | 1 | |a Chen, Yuqing |u Yuqing Chen [AFFILIATION="Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration | |
| 700 | 1 | |a Ji, Yuxiang |u Yuxiang Ji [AFFILIATION="Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration | |
| 700 | 1 | |a Lyu, Yongmei |u School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, China | |
| 700 | 1 | |a Miao, Zengli |u Clinical Medical Research Center, Department of Neurosurgery, Affiliated Wuxi Clinical College of Nantong University, Wuxi No.2 Peolpe’s Hospital, Jiangnan University Medical Center, Wuxi, China | |
| 700 | 1 | |a Duan, Xuchu |u Xuchu Duan [AFFILIATION="Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration | |
| 700 | 1 | |a Liu, Xiaoyu |u Xiaoyu Liu [AFFILIATION="Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration | |
| 773 | 0 | |t Frontiers in Immunology |g vol. 16 (Feb 2025), p. 1540199-1540211 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3278264270/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3278264270/fulltext/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3278264270/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |