Prediction of drug concentrations in humans for long-acting injectable suspensions by a semi-mechanical muscle compartment model: a case study of paliperidone palmitate

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書誌詳細
出版年:	Frontiers in Pharmacology vol. 16 (Jul 2025), p. 1507828-1507840
第一著者:	Yu, Panpan
その他の著者:	Zhang, Mengjun, Xiong, Jin, Wu, Keheng, Long, Sihui, Cheng, Shishi, Long, Fu, Xu, Xiao, Liu, Jie, Liu, Dan, Li, Xue, Liu, Bo, Xu, Jian
出版事項:	Frontiers Media SA
主題:	Diffusion coefficient Dissolution Pharmacokinetics Physicochemical properties Drug development Nanocrystals Computer simulation Particle size Anticoagulants Metabolism Palmitic acid Dogs Drug dosages
オンライン･アクセス:	Citation/Abstract Full Text Full Text - PDF
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その他の書誌記述
抄録:	Long-acting injectable formulations, such as paliperidone palmitate extended-release injectable suspension, have been designed to release medicines slowly and sustainably. Developing models that simulate drug release from long-acting injectable formulations in vivo is challenging. A novel approach to modeling and simulating complex and multiphasic drug pharmacokinetics (PK) is provided in this article to facilitate development of long-acting formulations. By segmenting nanocrystalline particles according to their different sizes, the absorption delays of each segment were obtained from the results of the PK study in dogs. In addition to the lag time for each segment, all other parameters, including physicochemical parameters such as drug solubility, density and diffusion coefficient, as well as pharmacokinetic parameters related to clearance, elimination and distribution, were introduced into the model to establish a muscle compartment model for use in humans. By using this model, the injectable suspensions paliperidone samples were predicted to have a long release of 90–100 days in vivo .
ISSN:	1663-9812
DOI:	1507828
ソース:	Biological Science Database