Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review
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| Pubblicato in: | Frontiers in Pharmacology vol. 16 (Sep 2025), p. 1644907-1644928 |
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| Altri autori: | , , , , , |
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Frontiers Media SA
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| Accesso online: | Citation/Abstract Full Text Full Text - PDF |
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| 022 | |a 1663-9812 | ||
| 024 | 7 | |a 1644907 |2 doi | |
| 035 | |a 3279100163 | ||
| 045 | 2 | |b d20250901 |b d20250930 | |
| 100 | 1 | |a Mittal, Rahul |u Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, United States, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States | |
| 245 | 1 | |a Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review | |
| 260 | |b Frontiers Media SA |c Sep 2025 | ||
| 513 | |a Systematic Review | ||
| 520 | 3 | |a IntroductionThe growing limitations of animal models in drug testing and biomedical research, including ethical concerns, high costs, and poor translational relevance to human biology, have driven increasing interest in computational simulation models. These models encompass in silico approaches, pharmacokinetic/pharmacodynamic frameworks, molecular simulations, and organ-on-chip technologies, offering greater precision in replicating human physiological and pathological processes.MethodsA systematic review was conducted to examine the role of computational simulation models as alternatives to traditional animal-based research. Relevant literature on their applications, predictive accuracy, translational value, and alignment with ethical research practices was analyzed.ResultsComputational models were found to bridge critical gaps in predictive accuracy and translational relevance, supporting drug development pipelines, reducing late-stage failures, and enhancing opportunities for personalized medicine. Additionally, their capacity to reduce reliance on animal models aligns with global ethical initiatives promoting humane and sustainable research practices.DiscussionSimulation-based approaches represent a transformative opportunity for biomedical research. While their potential to reshape drug development and improve health outcomes is evident, challenges such as standardization, scalability, and regulatory integration remain. Addressing these barriers will be essential to fully realize the potential of computational simulation models in replacing or reducing animal testing and advancing human-centered biomedical innovation.Systematic Review Registrationidentifier, INPLASY2024110028. | |
| 610 | 4 | |a Food & Drug Administration--FDA | |
| 653 | |a Physiology | ||
| 653 | |a Accuracy | ||
| 653 | |a Toxicity | ||
| 653 | |a Precision medicine | ||
| 653 | |a Boolean | ||
| 653 | |a Medical Subject Headings-MeSH | ||
| 653 | |a Drug testing | ||
| 653 | |a Biomedical research | ||
| 653 | |a Drug development | ||
| 653 | |a Computer simulation | ||
| 653 | |a Biology | ||
| 653 | |a Computer applications | ||
| 653 | |a Medical research | ||
| 653 | |a Metabolism | ||
| 653 | |a Ethics | ||
| 653 | |a Animal models | ||
| 653 | |a Medical innovations | ||
| 653 | |a Translation | ||
| 653 | |a Pharmacokinetics | ||
| 653 | |a Permeability | ||
| 653 | |a Bioengineering | ||
| 653 | |a Pharmacodynamics | ||
| 653 | |a Mathematical models | ||
| 653 | |a Systematic review | ||
| 700 | 1 | |a Ho, Alan |u Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, United States | |
| 700 | 1 | |a Adivikolanu, Harini |u Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, United States | |
| 700 | 1 | |a Sawhney, Muskaan |u Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, United States | |
| 700 | 1 | |a Lemos, Joana R N |u Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, United States, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States | |
| 700 | 1 | |a Mittal, Mannat |u Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, United States | |
| 700 | 1 | |a Hirani, Khemraj |u Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, United States, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States | |
| 773 | 0 | |t Frontiers in Pharmacology |g vol. 16 (Sep 2025), p. 1644907-1644928 | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3279100163/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3279100163/fulltext/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3279100163/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |