Azala

Distinct Clinical and Biological Features of Diffusely Metastatic Versus Bulky Localized Lung Cancer: Real-World Outcomes from a University Cancer Center in Germany

Gorde:
Argitaratua izan da:Cancers vol. 17, no. 23 (2025), p. 3728-3744
Egile nagusia: Resuli Blerina
Beste egile batzuk: Walter, Julia, Kauffmann-Guerrero, Diego, Behr Jürgen, Arnold, Paola, Götschke Jeremias, Leuschner Gabriela, Kovács, Julia, Eze Chukwuka, Schneider, Christian, Tufman Amanda
Argitaratua:
MDPI AG
Gaiak:
Patients
Histology
Medical prognosis
Metastasis
Regression analysis
Lung cancer
Immunotherapy
Age
Cancer therapies
Mutation
Adenocarcinoma
Biomarkers
Tumors
Biology
Metastases
Radiation therapy
Chemotherapy
Statistical analysis
Sarrera elektronikoa:Citation/Abstract
Full Text + Graphics
Full Text - PDF
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
Laburpena:Background: Lung cancer metastasis results from local invasion, loss of adhesion, migration, and distant implantation. Some small tumors metastasize diffusely other tumors progress to local bulky disease without metastasis. Here we compare these biologically divergent courses of progression and present an analysis of clinical features related to early diffuse metastasis vs. bulky disease. Methods: We retrospectively collected data from pathologically confirmed not-metastatic “bulky” (cT3-T4cN0cM0) or “diffusely metastatic” (cT1-T2cN1-3cM1) patients with lung cancer treated at our center from 2013 to 2023. Clinical data including sex, age, histology, ECOG-PS, tumor stage, smoking status, presence, and site of metastases, LDH, CRP, NLR ratio were collected. Results: A total of 375 patents with “bulky” (n = 95) or diffusely metastatic lung cancer (n = 280) were included in the analysis. In the univariate analysis, the diffusely metastatic population was younger (p = 0.001), had a higher proportion of never smokers (p = 0.02), histologically adenocarcinoma (p < 0.0001), TTF1 positive (p < 0.00001) and elevated baseline LDH in serum (LDH > 250U/l, p < 0.0001) compared to “bulky” population. Patients with diffuse metastatic disease presented worse OS (HR = 2.34, p = 0.0001) and PFS (HR = 6.89, p < 0.0001) compared to patients with bulky disease. Conclusions: Younger age, never smokers, TTF1 positivity, poorly differentiated tumors, adenocarcinoma histology were independently associated with risk of distant metastasis.
ISSN:2072-6694
DOI:10.3390/cancers17233728
Baliabidea:Biological Science Database