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Altered Effective Connectivity Patterns in MCI during Motion Detection Tasks

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Publicado en:Alzheimer's & Dementia vol. 21 (Dec 1, 2025)
Autor principal: Renli, Alina B
Otros Autores: Sun, Boxin, Gu, Ming, Kavcic, Voyko, Li, Tongtong, Giordani, Bruno
Publicado:
John Wiley & Sons, Inc.
Materias:
Causality
Pathology
Subjectivity
Brain
Discrimination
Brain research
Encoding (Cognitive process)
Regions
Complaints
Cognitive skills
Mapping
Brain activity
Cognition
Older people
Motion
Cognitive ability
Cognitive impairment
Tasks
Encoding
Electroencephalography
Time
Discrepancies
Patients
Temporal lobes
Hippocampus
Discrimination tasks
Alzheimer's disease
Acceso en línea:Citation/Abstract
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Resumen:Background Existing work suggests that Alzheimer's pathology can affect the direction and intensity of information signaling in functional brain regions. The present study aims to explore the impact of cognitive impairment on effectivity connectivity, as well as identify possible discrepancies between people with normal cognition (NC) and mild cognitive impairment (MCI) patients. Method Our research focuses on task‐based EEG (64‐channel), where participants were asked to perform a motion direction discrimination task. The current dataset includes 56 consensus‐diagnosed, community‐dwelling American seniors with subjective cognitive complaints (ages 60‐90 years, 28 NC and 28 MCI) recruited through the Wayne State University and Michigan Alzheimer’s Disease Research Center. For each participant, we evaluate the effective connectivity across all the possible EEG region pairs using causalized convergent cross‐mapping, a robust model for brain causality analysis based on state space reconstruction. Result Our results show that during the motion detection task, MCI patients exhibit lower effective connectivity in some EEG‐region pairs, especially between left temporal (LT) and left central (LC), and right temporal (RT) and right central (RC). This may be attributed to the fact that the temporal lobe, which encompasses the hippocampus, is largely involved in the encoding and processing of memory and visual motion capture. Concurrently, MCI patients exhibit significantly higher effective connectivity in other region pairs. Conclusion Altered effective connectivity measures may reflect compensatory brain activity among older individuals with MCI as they struggle to achieve comparable behavioral results to NC during the motion direction discrimination task. While effective connectivity may be decreased for MCI across certain region pairs, a significant increase in effective connectivity in some other regions pairs may be an indicator associated with AD and MCI pathology. Funding: NSF‐2032709/Li; NIH‐1R21AG046637‐01A1/Kavcic; NIH‐1R01AG054484‐01A1/Kavcic; NIH‐P30AG072931/Paulson and NIH‐P30AG024824/Yung.
ISSN:1552-5260
1552-5279
DOI:10.1002/alz70861_109006
Fuente:Consumer Health Database