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U.S. POINTER Study: Adherence to a Multidomain Health Behavior Change Intervention

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izdano v:Alzheimer's & Dementia vol. 21 (Dec 1, 2025)
Glavni avtor: Ventrelle, Jennifer
Drugi avtorji: Katula, Jeffrey A., Graef, Sarah, Garcia, Katelyn R, Heinrich, Allison, Wilmoth, Sharon, Nouran, Mina Ghadimi, Lambert, Katherine, Day, Claire E, Matongo, Olivia, McDonald, Ann Marie, Elbein, Richard, Antkowiak, Susan, Holley, Kellie, Treviño‐Whitaker, Rose, Miller, Kristie, Demos, Kathryn, Johnson, Justin Wade, Nichols, John E, Krueger, Kristin R, Tangney, Christy C, Morris, Martha Clare, Baker, Laura D
Izdano:
John Wiley & Sons, Inc.
Teme:
United States > US
Physical fitness
At risk populations
Cognitive functioning
Exercise
Intervention
Blood pressure
Behavior modification
Brain
Dementia
Resistance
Politics
Nutrition
Race
Health status
Older people
Aerobic exercise
Cognition
Ethnicity
Cognitive ability
Risk
Cognitive impairment
Behavior change
Diet
Leadership
Health behavior
Health education
Changes
Attendance
Peers
Alzheimer's disease
Adherence
Teams
Training
Fidelity
Clinical trials
Cognitive skills training
Accountability
Meetings
Adults
Computerization
Gift giving
Online dostop:Citation/Abstract
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Resumen:Background U.S. POINTER was a multisite randomized controlled trial testing the impact of multidomain lifestyle intervention on cognitive function in cognitively unimpaired older adults at risk for cognitive decline and dementia. Here we present the intervention adherence data. Methods U.S. POINTER randomly assigned over 2000 participants to one of two intervention arms, both targeting physical activity, nutrition, cognitive/social challenge and cardiometabolic risk reduction, but differing in intensity and accountability. The intervention prescription for the Structured (STR) arm included frequent peer team meetings (weekly for 16 weeks, bimonthly for 2 months, monthly thereafter), a structured exercise program using community facilities, a nutrition prescription modeled on the MIND diet, BrainHQ computerized cognitive training, regular cognitive/social challenge, and frequent monitoring of cardiometabolic health. The Self‐guided (SG) arm included a total of six peer team meetings, general health education covering all intervention domains, and gift cards to encourage healthy behaviors. Treatment fidelity assessments, guided by recommendations of the NIH Behavior Change Consortium, were conducted via annual site visits. Implementation of the intervention protocol was regularly monitored via monthly meetings with site intervention leadership to ensure consistency across study sites. Results Adherence tracking for the STR intervention arm included team meeting attendance (%), Fitbit activity (mean very active minutes/week), self‐reported exercise (aerobic, resistance, and balance mean minutes/week), MIND diet adherence (mean score/week), cognitive training (mean BrainHQ levels completed/week), cognitive/social activity (% of goal completed/week), and blood pressure checks (% of goal completed/month). SG intervention adherence was tracked using team meeting attendance. This topline presentation of U.S. POINTER's intervention adherence will provide metrics for the entire cohort and by subgroups based on age, biological sex, race, ethnicity, APOE genotype, baseline cardiometabolic health status, and baseline cognitive function. Conclusion U.S. POINTER's adherence metrics obtained in an ethnoracially and geographically diverse cohort (31% from underrepresented groups at 5 sites across the U.S.) will significantly inform our understanding of how to effectively facilitate behavior change to support brain health for older Americans at risk for Alzheimer's disease and related dementia.
ISSN:1552-5260
1552-5279
DOI:10.1002/alz70860_098285
Fuente:Consumer Health Database