Ultrafine particulate air pollution from wildfires and late‐life cognitive function in the KHANDLE and STAR cohorts
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| Publicado en: | Alzheimer's & Dementia vol. 21 (Dec 1, 2025) |
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| Otros Autores: | , , , , , |
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John Wiley & Sons, Inc.
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| Acceso en línea: | Citation/Abstract Full Text Full Text - PDF |
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| 001 | 3285997065 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1552-5260 | ||
| 022 | |a 1552-5279 | ||
| 024 | 7 | |a 10.1002/alz70860_103903 |2 doi | |
| 035 | |a 3285997065 | ||
| 045 | 0 | |b d20251201 | |
| 100 | 1 | |a Conlon, Kathryn C |u University of California, Davis, Davis, CA, USA, | |
| 245 | 1 | |a Ultrafine particulate air pollution from wildfires and late‐life cognitive function in the KHANDLE and STAR cohorts | |
| 260 | |b John Wiley & Sons, Inc. |c Dec 1, 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Background Substantial research has linked fine particulate matter (PM<2.5 μm in diameter, PM2.5) to cardiovascular disease and dementia, however, the role of ultrafine particulate matter (PM<0.1 μm in diameter, PM0.1), which is more readily absorbed into the bloodstream due to its smaller size, remains underexplored, especially in diverse populations. Method The study included data from n = 1648 adults aged ≥65 in the ethnically diverse Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study, and n = 746 African Americans in the Study of Healthy Aging in African‐Americans (STAR). Three domains of cognitive outcomes (semantic memory, verbal episodic memory, and executive function were measured using the Spanish and English Neuropsychological Assessment Scales and Z‐scored. Total PM0.1, and the fraction of PM0.1 from two sources (biomass combustion and wildland urban interface (WUI)), during 2000‐2020 were generated using a chemical transport model and linked to geocoded residential addresses. We used linear regression to assess the association between long‐term exposure to PM0.1 (5‐, 10‐, and 17‐year averages) and domain‐specific cognitive function adjusting for age, self‐reported gender, education (≤High School, Trade/College, and Graduate School), marital status (married/living as married, not married, missing), neighborhood income, and study. Effect modification by race/ethnicity was assessed using a multiplicative term, with p < 0.05 indicating significant effect modification. Result No associations were observed in main effects models (Figure 1). Effect modification by race and ethnicity was observed with 5‐year WUI PM0.1 exposures across all cognitive domains (p < 0.05). Among non‐Latino white participants, an IQR increase in 5‐year average WUI PM0.1 was associated with a decrease in cognition across all cognitive domains (Figure 1). Among Latino participants, an IQR increase in 5‐year average total PM0.1 was associated with decreased verbal episodic memory. Associations were attenuated or null for 10‐ and 17‐year exposures. Conclusion Long‐term WUI PM0.1 exposure was associated with decreased cognitive function among non‐Latino white participants. Wildfires are an increasing threat in California, and more research on their impact on cognition is needed. | |
| 653 | |a Cognitive functioning | ||
| 653 | |a Episodic memory | ||
| 653 | |a Aging | ||
| 653 | |a Semantic memory | ||
| 653 | |a Function | ||
| 653 | |a Dementia | ||
| 653 | |a Secondary schools | ||
| 653 | |a Race | ||
| 653 | |a African Americans | ||
| 653 | |a Cognition | ||
| 653 | |a Ethnicity | ||
| 653 | |a Cognitive ability | ||
| 653 | |a Air pollution | ||
| 653 | |a Hispanic Americans | ||
| 653 | |a Cognition & reasoning | ||
| 653 | |a Marital status | ||
| 653 | |a Graduate studies | ||
| 653 | |a Latin American cultural groups | ||
| 653 | |a Life experiences | ||
| 653 | |a Memory | ||
| 653 | |a Multiculturalism & pluralism | ||
| 653 | |a Spanish language | ||
| 653 | |a Averages | ||
| 653 | |a Neighborhoods | ||
| 653 | |a Verbal memory | ||
| 653 | |a Marriage | ||
| 653 | |a Neuropsychological assessment | ||
| 653 | |a Cardiovascular diseases | ||
| 653 | |a Executive function | ||
| 653 | |a Adults | ||
| 653 | |a Forest & brush fires | ||
| 700 | 1 | |a Goodrich, Amanda |u University of California Davis, Davis, CA, USA, | |
| 700 | 1 | |a Alexeeff, Stacey |u Kaiser Permanente Northern California Division of Research, Pleasanton, CA, USA, | |
| 700 | 1 | |a Tsai, Ai‐Lin |u Kaiser Permanente Northern California Division of Research, Pleasanton, CA, USA, | |
| 700 | 1 | |a Gilsanz, Paola |u Kaiser Permanente Northern California Division of Research, Pleasanton, CA, USA, | |
| 700 | 1 | |a Kleeman, Mike |u UC Davis, Davis, CA, USA, | |
| 700 | 1 | |a Whitmer, Rachel A. |u University of California, Davis, Davis, CA, USA, | |
| 773 | 0 | |t Alzheimer's & Dementia |g vol. 21 (Dec 1, 2025) | |
| 786 | 0 | |d ProQuest |t Consumer Health Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3285997065/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
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| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3285997065/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |