Slika omota

Predicted Role of Mitsugumin 23 in Skeletal and Cardiac Muscle

Spremljeno u:
Izdano u:Cells vol. 14, no. 24 (2025), p. 1958-1973
Glavni autor: Watanabe Daiki
Daljnji autori: Edel, Richard C, Nishi Miyuki, Takeshima, Hiroshi, Pitt, Samantha J
Izdano:
MDPI AG
Teme:
Physiology
Signal transduction
Homeostasis
Sarcoplasmic reticulum
Calcium
Musculoskeletal system
Skeletal muscle
Permeability
Congestive heart failure
Microscopy
Medical research
Muscle contraction
Mitochondria
Muscle function
Leak channels
Cardiac muscle
Proteins
Online pristup:Citation/Abstract
Full Text + Graphics
Full Text - PDF
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
Sažetak:Mitsugumin 23 (MG23) is a transmembrane protein expressed in the nuclear membrane and endo/sarcoplasmic reticulum (ER/SR) of various tissues, including skeletal and cardiac muscle. MG23 is a non-selective cation channel that has been implicated in the leakage of calcium ions (Ca2+) under diverse pathophysiological conditions. SR Ca2+ leak is considered to be a contributing factor of skeletal muscle weakness and is also implicated in the progression of heart failure. The absence of MG23 has been reported to alleviate negative outcomes associated with SR Ca2+ leak. Targeting MG23 could represent a new therapeutic strategy against muscle disorders. This review discusses the potential role of MG23 in skeletal and cardiac muscle, and highlights MG23 as both a regulator of basal SR Ca2+-handling and a mediator of pathophysiological remodelling in muscle.
ISSN:2073-4409
Digitalni identifikator objekta:10.3390/cells14241958
Izvor:Biological Science Database