Εξώφυλλο

Cognitive profiles in primary progressive aphasia and its variants

Αποθηκεύτηκε σε:
Εκδόθηκε σε:Alzheimer's & Dementia vol. 21 (Dec 1, 2025)
Κύριος συγγραφέας: Fernandez‐Romero, Lucia
Άλλοι συγγραφείς: Oliver‐Mas, Silvia, Delgado‐Alonso, Cristina, Díez‐Cirarda, María, Valiente‐Gordillo, Esther, López‐Carbonero, Juan Ignacio, Matias‐Guiu, Jorge, Gil‐Moreno, María José, Matias‐Guiu, Jordi A
Έκδοση:
John Wiley & Sons, Inc.
Θέματα:
Diagnostic tests
Episodic memory
Classification
Medical diagnosis
Aphasia
Cognition
Recall
Language disorders
Semantics
Ability
Variants
Executive function
Short term memory
Disease
Biological markers
Attention
Memory
Patients
Groups
Visual memory
Spatial memory
Visual-Spatial ability
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Περίληψη:Background Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by the progressive impairment of language abilities. However, recent findings suggest that other cognitive domains, beyond language, may also be affected in the early stages of the disease. Exploring cognitive domains could facilitate the diagnosis of PPA and its classification into the three main variants (non‐fluent (nfvPPA), semantic (svPPA) and logopenic (lvPPA)), which remains challenging. This study aimed to identify non‐linguistic cognitive alterations in PPA and its variants. Method A cross‐sectional study including 157 patients with PPA and 74 cognitively unimpaired controls. Patients were classified into nfvPPA (N = 58), svPPA (N = 19), and lvPPA (N = 80) using a language battery, FDG‐PET, and CSF biomarkers. The mean age was 69,97 ± 8.12 years, and the 61.04% were females. Four cognitive domains (attention and working memory, executive functions, episodic memory and visuospatial abilities) were assessed using the ACE‐III and the following cognitive tests: Digit Span, TMT‐A and B, Rey‐Osterrieth Complex Figure (copy and 3‐minute recall), VOSP and Tower of London. Result All PPA variants scored significantly worse than the control group across most explored domains. The lvPPA and svPPA groups scored lower on episodic memory compared to the nfvPPA group. The lvPPA group performed worse on visuospatial abilities and executive function than the svPPA group. The nfvPPA group scored lower on attention and working memory tasks compared to the svPPA group. Conclusion This study highlights the impairment of non‐linguistic cognitive domains in PPA and its variants, identifying distinct cognitive profiles across variants that may aid in the patient diagnosis, classification, and monitoring of disease progression.
ISSN:1552-5260
1552-5279
DOI:10.1002/alz70857_099014
Πηγή:Consumer Health Database