תמונות העטיפה

Associations Between Self‐reported History of Traumatic Brain Injury on Longitudinal Cognitive and Speech Changes Linked to Alzheimer's Disease Risk Factors

שמור ב:
הוצא לאור ב:Alzheimer's & Dementia vol. 21 (Dec 1, 2025)
מחבר ראשי: Goulette, Olivia
מחברים אחרים: He, Deling, Basche, Kristin E, Langhough, Rebecca E., Betthauser, Tobey J., Hermann, Bruce P, Johnson, Sterling C, Mueller, Kimberly D
יצא לאור:
John Wiley & Sons, Inc.
נושאים:
Indexes
Alzheimer's disease
Accumulation
Injuries
Fluency
Pathology
Age groups
Risk factors
Brain
Politics
Speech
Retrieval
Cognition
Genetics
Cognitive functioning
Phonology
Trauma
Brain damage
History
Traumatic brain injury
Semantic categories
Phonological processing
Executive function
Lexical access
Letters (Correspondence)
Change agents
Biological markers
Language shift
Semantic processing
Disease
Changes
Semantics
גישה מקוונת:Citation/Abstract
Full Text
Full Text - PDF
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
Resumen:Background While both traumatic brain injury (TBI) and Alzheimer's disease (AD) are known to impair cognitive, language, and speech abilities, little to no research examines how a history of TBI interacts with AD‐related predictors (e.g., amyloid and tau pathology, familial genetic factors) to influence longitudinal changes in cognitive and language outcomes. Method We included 308 cognitively unimpaired participants from the Wisconsin Registry for Alzheimer's Prevention (WRAP) with available amyloid and tau PET imaging, APOE ε4 genetic status, and self‐reported TBI history (TBI‐=0, TBI+ >=1). Within each of three AD risk groups (i.e., A+, T+, or APOE e4 carriers), we examined TBI history*age interactions in relationship with cognitive‐language outcomes using linear mixed‐effects models, adjusting for sex, and WRAT‐3 score [i.e., outcomes ∼ TBI group * age +sex+ WRAT‐3+ (1|ID)]. We examined standardized cognitive measures of executive functioning/set‐shifting (i.e., Digit Symbol Coding Test, Trail Making Test B Score), semantic‐phonological processing (i.e., animal category fluency, letter fluency [C, F, L]), and connected speech measures from picture description (i.e., Fluency Index, Words per Minute, Correct‐Information‐Units/total words). Result In the A+ subset (Ntotal=108, NTBI+=35, NTBI‐=73;, Table 1), we found that the TBI+ group exhibited greater average decline in letter fluency (p = 0.036) and the fluency index (i.e., increases in disfluent behavior; p =  0.035) compared to those without TBI (Figure 1). No significant associations were observed between TBI history and longitudinal changes outcomes in the sample of tau+ (Ntotal=73, NTBI+=25, NTBI‐=48) and APOE ε4 allele carriers (Ntotal=127, NTBI+=40, NTBI‐=87). Conclusion Our findings suggest that TBI, in combination with early AD amyloid accumulation, may accelerate communication declines, particularly manifesting as reduced letter fluency and increased speech disfluency. Presumably, these results indicate increased challenges in semantic and phonological retrieval due to the compounded impact of TBI and AD pathology in individuals who are cognitively unimpaired. Our study identifies potential early language indicators of decline; future analyses will investigate more complex TBI/biomarker relationships and additional outcomes.
ISSN:1552-5260
1552-5279
DOI:10.1002/alz70857_107250
Fuente:Consumer Health Database