Imagen de Portada

Relationship between genetic risk and p‐tau concentration on cognitive performance in a multiethnic population from Peru

Guardado en:
Publicado en:Alzheimer's & Dementia vol. 21 (Dec 1, 2025)
Autor principal: Rivera‐Fernandez, Claudia
Otros Autores: Custodio, Nilton, Montesinos, Rosa, Muñoz‐Najar, Andres, Reyes‐Dumeyer, Dolly, Tosto, Giuseppe, Soto‐Añari, Marcio
Publicado:
John Wiley & Sons, Inc.
Materias:
Peru
Episodic memory
Alzheimer's disease
Memory
Dementia
Older people
Cognition
Ethnicity
Risk
Cognitive impairment
Genetics
Multiracial people
Delayed memory
Concentration
Biological markers
Genetic susceptibility
Minority groups
Health risk assessment
Tests
Short term memory
Delayed recall
Ethnic groups
Adults
Cognitive ability
Indigenous peoples
Disease
Biomarkers
Risk factors
Acceso en línea:Citation/Abstract
Full Text - PDF
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Resumen:Background The presence of APOE 4 is considered the main genetic risk factor for the development of dementia. Additionally, plasma p‐tau has been shown to be an important biomarker associated with Alzheimer's disease. However, these factors have been understudied in Latin American ethnic minorities, such as the Quechuas and Aymaras. Our objective was to analyze the relationship between genetic risk and p‐tau concentration on cognitive performance in a multiethnic population from Peru. Method We extracted data from the Genetics of Alzheimer's Disease in Peruvian Populations (GAPP) study (Pandey et al., 2025). We included healthy cognitive controls and mild cognitive impairment (MCI) participants. A total of 432 older adults (Mean Age&#xa0;=&#xa0;70.77, SD&#xa0;=&#xa0;7.66) were assessed using the Rowland Universal Dementia Assessment Scale (RUDAS) for general mental status, the Selective Reminding Test (SRT) for delayed memory, Benton's visual working memory test, and the Rosen test for visuoconstruction. APOE genotyping and plasma sample collection for biomarker identification are detailed in Pandey et al. (2025). Result We observed that 55.56% of the older adults were healthy controls (40% mestizo, 60% indigenous), while 44.44% had been diagnosed with MCI (40% mestizo, 60% indigenous). Regression analysis showed that participants carrying at least one APOE allele (E3/E4 or E4/E4) and with higher p‐tau217 concentrations performed worse on delayed recall in the SRT (B&#xa0;=&#xa0;‐2.506; p&#xa0;<&#xa0;.015), but not on the RUDAS, Rosen test, or Benson test. This effect did not appear to be mediated by ethnicity. Further analyses differentiated by ethnicity showed that being indigenous was associated with better scores on the Rosen test (B&#xa0;=&#xa0;0.608; p&#xa0;<&#xa0;.000), while being mestizo was associated with better performance on the Benton recognition test (B&#xa0;=&#xa0;‐1.09; p&#xa0;<&#xa0;.000) and general cognition (B&#xa0;=&#xa0;‐2.084; p&#xa0;<&#xa0;.016). Conclusion The presence of APOE and p‐tau217 concentration modulate episodic memory performance, while ethnicity appears to influence visuospatial, visuoconstructive, and general cognitive processes.
ISSN:1552-5260
1552-5279
DOI:10.1002/alz70856_103195
Fuente:Consumer Health Database