Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice
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| Publicat a: | International Journal of Immunopathology and Pharmacology vol. 39 (Jun 2025) |
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| Autor principal: | |
| Altres autors: | , , , , |
| Publicat: |
Sage Publications Ltd.
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| Matèries: | |
| Accés en línia: | Citation/Abstract |
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| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3287004908 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 0394-6320 | ||
| 022 | |a 2058-7384 | ||
| 024 | 7 | |a 10.1177/03946320251348715 |2 doi | |
| 035 | |a 3287004908 | ||
| 045 | 2 | |b d20250601 |b d20250630 | |
| 100 | 1 | |a Shu-Ping, Kung |u Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taiwan, China, R.O.C. | |
| 245 | 1 | |a Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice | |
| 260 | |b Sage Publications Ltd. |c Jun 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited treatment options and associated side effects or resistance. This study aims to investigate the therapeutic potential of the natural compound cucurbitacin B (CuB) in RA treatment. Methods: We utilized a collagen-induced arthritis (CIA) mouse model to evaluate the effects of CuB. Arthritis scores, histological damage, and pro-inflammatory cytokine expression (TNF-α, IL-17A) were assessed. In addition, network pharmacology analysis was performed to explore CuB’s molecular mechanisms, focusing on Th17 cell differentiation, IL-17 signaling, and the JAK-STAT pathway. Results: CuB significantly reduced arthritis severity, decreased histological damage, and lowered the expression of pro-inflammatory cytokines in CIA mice. CuB was found to inhibit STAT3 phosphorylation and reduce the proportion of Th17 cells in the spleen, indicating its potential anti-inflammatory effects. Conclusion: These findings suggest that cucurbitacin B may serve as a promising novel therapeutic agent for rheumatoid arthritis by targeting key inflammatory pathways. | |
| 610 | 4 | |a Central Intelligence Agency--CIA | |
| 653 | |a Helper cells | ||
| 653 | |a Molecular modelling | ||
| 653 | |a Rheumatoid arthritis | ||
| 653 | |a Cell differentiation | ||
| 653 | |a Phosphorylation | ||
| 653 | |a Tumor necrosis factor-α | ||
| 653 | |a Autoimmune diseases | ||
| 653 | |a Lymphocytes T | ||
| 653 | |a Collagen | ||
| 653 | |a Stat3 protein | ||
| 653 | |a Inflammation | ||
| 700 | 1 | |a Hira, Umbreen |u Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan, China, R.O.C. | |
| 700 | 1 | |a Wang Jou-Hsuan |u Department of Physical Medicine and Rehabilitation, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, China, R.O.C. | |
| 700 | 1 | |a Chih-Ming, Tsia |u Division of Infectious Diseases, Department of Pediatrics, University of California, La Jolla, CA, USA, R.O.C. | |
| 700 | 1 | |a Lin Tim Chi-Chen |u Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taiwan, China, R.O.C. | |
| 700 | 1 | |a Yu-Ting, Chen |u Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan, China, R.O.C. | |
| 773 | 0 | |t International Journal of Immunopathology and Pharmacology |g vol. 39 (Jun 2025) | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3287004908/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |