Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation
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| Опубликовано в:: | Nature Communications vol. 16, no. 1 (2025), p. 11700-11716 |
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| Главный автор: | |
| Другие авторы: | , , , |
| Опубликовано: |
Nature Publishing Group
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| Online-ссылка: | Citation/Abstract Full Text Full Text - PDF |
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| 100 | 1 | |a Jang, Hyunwoo |u Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370) | |
| 245 | 1 | |a Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation | |
| 260 | |b Nature Publishing Group |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a The neural basis of consciousness remains incompletely understood. While cortical mechanisms of conscious perception have been extensively investigated in humans, the role of subcortical structures, including the thalamus, remains less explored. Here, we elucidate the causal contributions of different thalamic regions to conscious perception using transcranial low-intensity focused ultrasound (LIFU) neuromodulation. We hypothesize that modulating distinct thalamic regions alters perceptual outcomes derived from Signal Detection Theory. We apply LIFU to healthy human anterior (transmodal-dominant) and posterior (unimodal-dominant) thalamic regions, further subdivided into ventral and dorsal regions, during a near-threshold visual perception task. We show that high duty cycle modulation of the ventroanterior (VA) part of thalamus enhances object recognition sensitivity. Sensitivity enhancement magnitude correlates with the core-matrix cell compositions of the stimulated thalamic region. Connectivity analysis of a large-scale functional magnetic resonance imaging dataset confirms strong transmodal connectivity of VA thalamus with frontoparietal and default-mode networks. We also demonstrate target-invariant effects of high duty cycle LIFU disrupting object categorization accuracy. These findings provide causal insight into the cytoarchitectural and functional organization of the thalamus that shape human visual experience, especially the role of matrix-cell-rich, transmodal-dominant VA thalamus.Using low-intensity focused ultrasound, the authors show that targeted modulation of specific thalamic subregions alters human visual perception, revealing a causal role of the anterior thalamus in shaping conscious experience. | |
| 653 | |a Visual tasks | ||
| 653 | |a Visual perception | ||
| 653 | |a Magnetic resonance imaging | ||
| 653 | |a Functional magnetic resonance imaging | ||
| 653 | |a Sensitivity enhancement | ||
| 653 | |a Functional morphology | ||
| 653 | |a Modulation | ||
| 653 | |a Hypotheses | ||
| 653 | |a Signal detection | ||
| 653 | |a Pattern recognition | ||
| 653 | |a Ultrasound | ||
| 653 | |a Neuromodulation | ||
| 653 | |a Thalamus | ||
| 653 | |a Visual thresholds | ||
| 653 | |a Perception | ||
| 653 | |a Consciousness | ||
| 653 | |a Connectivity analysis | ||
| 653 | |a Object recognition | ||
| 653 | |a Ultrasonic imaging | ||
| 653 | |a Neural networks | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Fotiadis, Panagiotis |u Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370) | |
| 700 | 1 | |a Mashour, George A. |u Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Michigan Psychedelic Center, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370) | |
| 700 | 1 | |a Hudetz, Anthony G. |u Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Michigan Psychedelic Center, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370) | |
| 700 | 1 | |a Huang, Zirui |u Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370); Michigan Psychedelic Center, University of Michigan Medical School, Ann Arbor, MI, USA (ROR: https://ror.org/00jmfr291) (GRID: grid.214458.e) (ISNI: 0000000086837370) | |
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