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Acute and sub acute oral toxicity study of the ethanolic extract of leaves from Hamelia patens (Rubiceae) in mice

The ethanol extract of leaves from Hamelia patens was evaluated for acute and sub-acute oral toxicity. The single oral doses of the ethanol extract at 5, 50, 300, and 2000 mg/kg body weight did not produce mortality or significant changes in the general behaviors. In the sub-acute toxicity study, th...

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Kaydedildi:
Asıl Yazarlar: Escobar, María H., Sanchez-Perez, Juan Pablo, Avalos, Jesús N., Mejía, José G., Toloza , Simon G., Núñez, Marvin J., Moreno, Miguel A.
Materyal Türü: Online
Dil:İspanyolca
Baskı/Yayın Bilgisi: Secretaría de Investigaciones Cien´tíficas de la Universidad de El Salvador 2021
Konular:
Hamelia patens
acute toxicity
subacute toxicity
toxicidad aguda
toxicidad subaguda
Online Erişim:https://minerva.sic.ues.edu.sv/Minerva/article/view/104
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Özet:The ethanol extract of leaves from Hamelia patens was evaluated for acute and sub-acute oral toxicity. The single oral doses of the ethanol extract at 5, 50, 300, and 2000 mg/kg body weight did not produce mortality or significant changes in the general behaviors. In the sub-acute toxicity study, the ethanol extract was administrated orally at a dose of 2000 mg/km/day for 28 days. The results show a CL50 up from 2000 mg/kg, which is indicative of safe use for the human being because does not represent serious alterations in the state of health of the experimental animals.

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