Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors
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| Udgivet i: | Journal of Applied Physiology vol. 117, no. 4 (Aug 15, 2014), p. 345 |
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| Andre forfattere: | , , , , , , , , , , , , |
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American Physiological Society
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| Online adgang: | Citation/Abstract |
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| 100 | 1 | |a Green, Daniel J | |
| 245 | 1 | |a Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors | |
| 260 | |b American Physiological Society |c Aug 15, 2014 | ||
| 513 | |a Feature | ||
| 520 | 3 | |a The objectives of our study were to examine 1) the proportion of responders and nonresponders to exercise training in terms of vascular function; 2) a priori factors related to exercise training-induced changes in conduit artery function, and 3) the contribution of traditional cardiovascular risk factors to exercise-induced changes in artery function. We pooled data from our laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type exercise training interventions with pre-/posttraining measures of flow-mediated dilation (FMD%) to assess artery function. All studies adopted an identical FMD protocol (5-min ischemia, distal cuff inflation), contemporary echo-Doppler methodology, and observer-independent automated analysis. Linear regression analysis was used to identify factors contributing to changes in FMD%. We found that cardiopulmonary fitness improved, and weight, body mass index (BMI), cholesterol, and mean arterial pressure (MAP) decreased after training, while FMD% increased in 76% of subjects (P < 0.001). Training-induced increase in FMD% was predicted by lower body weight (β = -0.212), lower baseline FMD% (β = -0.469), lower training frequency (β = -0.256), and longer training duration (β = 0.367) (combined: P < 0.001, r = 0.63). With the exception of a modest correlation with total cholesterol (r = -0.243, P < 0.01), changes in traditional cardiovascular risk factors were not significantly related to changes in FMD% (P > 0.05). In conclusion, we found that, while some subjects do not demonstrate increases following exercise training, improvement in FMD% is present in those with lower pretraining body weight and endothelial function. Moreover, exercise training-induced change in FMD% did not correlate with changes in traditional cardiovascular risk factors, indicating that some cardioprotective effects of exercise training are independent of improvement in risk factors. | |
| 653 | |a Exercise | ||
| 653 | |a Veins & arteries | ||
| 653 | |a Cardiovascular disease | ||
| 653 | |a Risk factors | ||
| 653 | |a Regression analysis | ||
| 653 | |a Body mass index | ||
| 653 | |a Cholesterol | ||
| 653 | |a Physical training | ||
| 653 | |a Body weight | ||
| 653 | |a Health risks | ||
| 653 | |a Social | ||
| 700 | 1 | |a Eijsvogels, Thijs | |
| 700 | 1 | |a Bouts, Yvette M | |
| 700 | 1 | |a Maiorana, Andrew J | |
| 700 | 1 | |a Naylor, Louise H | |
| 700 | 1 | |a Scholten, Ralph R | |
| 700 | 1 | |a Spaanderman, Marc E A | |
| 700 | 1 | |a Pugh, Christopher J A | |
| 700 | 1 | |a Sprung, Victoria S | |
| 700 | 1 | |a Schreuder, Tim | |
| 700 | 1 | |a Jones, Helen | |
| 700 | 1 | |a Cable, Tim | |
| 700 | 1 | |a Hopman, Maria T E | |
| 700 | 1 | |a Thijssen, Dick H J | |
| 773 | 0 | |t Journal of Applied Physiology |g vol. 117, no. 4 (Aug 15, 2014), p. 345 | |
| 786 | 0 | |d ProQuest |t Biological Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/1555410234/abstract/embedded/J7RWLIQ9I3C9JK51?source=fedsrch |